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Enantioselective Diamination of Alkenes, Hydroamination of 1,3-Dienes, and the Development of NHC Palladium Complexes
Nitrogen containing heterocylces make up a vast majority of biologically relevant small molecules. Using transition metal catalysts to directly synthesize functionalized amine heterocycles is a valuable and efficient tool in chemical synthesis. Herein, the development of two palladium-catalyzed transformations are described; ...
Development of Palladium and Hypervalent Iodine(III) Catalyzed Alkene Difunctionalization Reactions; Hydroamination, Carboamination, Aminofluorination & Diamination
The investigation and development of synthetic methodologies for direct alkene difunctionalization is described. The utility of these processes is demonstrated by the synthesis of a number of functionalized nitrogen-containing heterocycles, including pyrrolidines and morpholines. As these are commonly-encountered motifs in a ...
Label Transfer Reagents for the Investigation of Protein Kinase Complexes
Protein kinases are essential enzymes for cellular signaling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interactions with other signaling proteins. However, the weak and transient nature of ...
Copper-Catalyzed Reactions of Organoboron Compounds
The discovery, development, scope, and mechanistic studies of three new copper-catalyzed transformations of organoboron compounds are described herein. Specifically, Chapter 1 details the development and scope of the first general method for SN2'-selective substitution of primary allylic chlorides using aryl boronic esters ...
Cross-Conjugated Moieties as Design Motifs for a Class of Novel Electro-Optic Chromophores
Organic electro-optic materials are at the forefront of current photonics applications that enable high speed data transmission, micro-scale sensors, and terahertz applications. Typically linearly conjugated push-pull type chromophores are the primary molecules of choice for various second and third order non-linear optical ...