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A Broadband Optical Ring Resonator for Absorption and Refractive Index Detection
Optical ring resonators have been studied in recent years as chemical sensors. Conventionally, these devices are operated by means of tracking a single resonance wavelength through use of a finely tunable laser source. This wavelength will shift as a result of changing resonator conditions, such as a refractive index (RI) ...
Single-Molecule Studies for the Characterization of Synaptic Vesicles
Synaptic vesicles are subcellular organelles that are found in the synaptic bouton and are responsible for the propagation of signals between neurons. Synaptic vesicles undergo a fast and tightly regulated cycle in which exocytosis to release neurotransmitters and endocytosis to recycle empty vesicles take place for efficient ...
The Clinical Diagnosis of Porphyrias by Tandem Mass Spectrometry
Heme, a tetrapyrrole ringed molecule essential for life, is synthesized by the body in an eight-step, enzyme-assisted pathway. Each step is catalyzed by an enzyme; a genetic deficiency in any of the last seven of these enzymes is classified as a type of the family of diseases called the porphyrias. Tandem mass spectrometry, ...
New Electrochemical Methods for Studying Nanoparticle Electrocatalysis and Neuronal Excocytosis
This dissertation presents the construction and application of micro and nanoscale electrodes for electroanalytical analysis. The studies presented herein encompass two main areas: electrochemical catalysis, and studies of the dynamics of single cell exocytosis. The first portion of this dissertation engages the use of Pt ...