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Single-Molecule Studies for the Characterization of Synaptic Vesicles
Synaptic vesicles are subcellular organelles that are found in the synaptic bouton and are responsible for the propagation of signals between neurons. Synaptic vesicles undergo a fast and tightly regulated cycle in which exocytosis to release neurotransmitters and endocytosis to recycle empty vesicles take place for efficient ...
Design and Characterization of Novel Tandem Ion Mobility Mass Spectrometry Instrumentation
Native ion mobility (IM) mass spectrometry (MS) is a gas-phase structural biology technique that couples low-pressure, electrophoretic separation of ions with mass detection to provide low-resolution information on the size, shape, and charge of biomolecules such as peptides and protein assemblies. Soft ionization techniques ...