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Understanding Src Kinase Regulatory Mechanisms and Drug Resistance Using Deep Mutational Scanning and Chemical Biology
Protein phosphorylation controls a wide variety of cellular processes such as growth, differentiation, proliferation, and apoptosis in eukaryotes. Kinases are signaling enzymes that dictate cellular phosphorylation state by phosphorylating specific protein substrates. Over 530 protein kinases are encoded by the human genome ...