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Utilizing Molecular Dynamics' Multipotent Methodologies to Measure Microscopic Motions of DNA Molecules: A Magniloquent Manuscript on DNA’s Means and Mannerisms
DNA is an amazing molecule which is the basic template for all genetics. It is the primary molecule for storing biological information, and has many applications in nanotechnology. Double-stranded DNA may contain mismatched base pairs beyond the Watson-Crick pairs guanine-cytosine and adenine-thymine. To date, no one has found ...
Sterol-phospholipid interactions in model lipid membranes
Cell membranes feature complex intermolecular interactions between phospholipids and sterols. In this dissertation, I discuss how the accessibility (a measure of chemical activity) of cholesterol in a lipid bilayer varies as a function of bilayer composition. By using the two complementary cyclodextrins (methyl-beta and ...
Electronic and Geometric Structure of Biological Spin Centers Investigated with EPR Spectroscopy
In this dissertation, the fundamental concepts and techniques of electron paramagnetic resonance (EPR) spectroscopy, which are important for understanding electronic structure and relating it to geometric structure, are presented in Chapter 1. Following this are five chapters each dedicated to a separate topic where EPR ...
Applications of Physical Chemistry in Solar Energy, Membrane Biophysics, and Cultural Heritage
This dissertation records detailed applications of concepts and techniques in physical chemistry to a wide range of systems. Topics include: 1) A review of electrical scanning probe microscopy (SPM) methods for analyzing properties of solar energy materials, particularly organic photovoltaics (OPVs), on the nanoscale. 2) ...
New Statistical Inference Methods for DEER Spectroscopy on Proteins
Double Electron-Electron Resonance (DEER) spectroscopy is a pulse-EPR experiment that can provide sub-ångström resolution distance measurements of proteins and other biomacro- molecules in the distance range of about 2-16 nm. It is growing in importance as a tool for structural biology and, due to its robustness towards ...
Theoretical and Computational Studies of the Lateral Phases on a Multicomponent Lipid-Bilayer Surface
The lipid-bilayer membrane is the fundamental structure of a cell plasma membrane and has been largely studied by biophysical experiments, theoretical modeling and computer simulations. Two major aspects of lipid bilayer morphologies are studied, namely lateral phase separation and pattern formation (spatial organization of ...
Lipid Membranes: From Organizational Strategies in Cells to the Origins of Life
Lipids, a fundamental building block of cells, can spontaneously self-assemble into vesicles, which are spherical shells consisting of a lipid bilayer. The structure of lipid bilayers determines their biological function: membranes are elastic, selectively permeable, and fluid barriers that separate the internal components ...
Fundamentals and Applications of Biological EPR Spectroscopy
This thesis details robust experimental investigations of sample conditions for EPR spectroscopy. This work investigates two areas of sample conditions. First, a robust experimental investigation of the effect of sample matrix deuteration on relaxation behavior is presented. This work serves to guide experimental practitioners ...