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Sorting through the JuNK: Using Chemical and Genetic Tools to Probe c-Jun N-Terminal Kinase Allostery and Scaffolding, as well as a General Methodology for Studying Localized Kinase Biology
This dissertation explores the complicated nature of protein kinase allostery and the use of ATP-competitive inhibitors as tools to study kinase function. Much of this work focuses on the c-Jun N-Terminal Kinases (JNKs), a subfamily of the Mitogen Activate Protein Kinases (MAPK), which are involved in a broad range of signaling ...