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Label Transfer Reagents for the Investigation of Protein Kinase Complexes
(2013-02-25)
Protein kinases are essential enzymes for cellular signaling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interactions with other signaling proteins. However, the weak and transient nature of ...
Characterization and Exploitation of Bidirectional Allosteric Coupling in Multi-Domain Tyrosine Kinases using Conformation-Selective ATP-Competitive Inhibitors
Protein kinases are a large family of enzymes that play integral roles in cell signaling networks and are thus critical for effecting appropriate cellular responses to environmental stimuli. Much of kinase biological function has been studied in terms of catalytic activity: phosphorylation of substrate proteins as part of ...
Biological applications of designed hairpin peptides: as antimicrobials and as inhibitors of amyloidogenesis
More than 40 diseases have been associated with the misfolding of peptides (or proteins) that form fibrils with a very specific morphology. These peptides classified as amyloidogenic peptides have been implicated in the development of Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, Hungtinton’s Disease etc. To ...
Caps - Turns - Loops: Designing Better β-Hairpins
As protein engineering promises advances in almost every field of science and medicine, a greater understanding of the protein folding problem is necessary to make these innovations a reality. This thesis examines one type of folded structure, the β-sheet. By designing several new peptide systems, the thermodynamics and ...
Developing Catalytically Active Living Materials for Additive Manufacturing
Living materials are created through the embedding of live, whole cells into a matrix that can house and sustain the viability of the encapsulated cells. Through the cell immobilization process, their bioactivity (natural or engineered) can be harnessed for applications such as the production of high-value chemicals or ...