Now showing items 31-40 of 71
The biosynthesis of the thiopeptide antibiotic thiostrepton
Thiostrepton is a sulfur rich, highly modified peptide antibiotic produced by the soil bacteria Streptomyces laurentii, Streptomyces azureus , and Streptomyces hawaiiensis. It is a member of the structurally similar thiopeptide antibiotic family. Thiostrepton has been found to show strong antibiotic activity towards Gram-positive ...
Theory guided design and molecular engineering of organic materials for enhanced second-order nonlinear optical properties
The last two decades of research in the field of organic 2nd-order nonlinear optical (electro-optic) materials has led to a deeper understanding of salient fundamental processes. Detailed definitions of critical structure-property relationships have led to the realization of new materials displaying dramatically enhanced ...
Discovery based yeast metabolomic analysis using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry and chemometrics
Comprehensive two-dimensional (2D) separations are highly beneficial in the characterization of complex samples. The research presented in this dissertation involves the analysis of the small polar molecules comprising the yeast metabolome using commercially available GCxGC-TOFMS instrumentation. The studies described herein ...
Anisotropic potential energy surfaces for atmospheric gas: unsaturated hydrocarbon molecule interactions from differential scattering experiments
The total differential scattering cross sections of several atmospheric gas-unsaturated hydrocarbon molecule systems (He, Ne, Ar, H$\sb2$, N$\sb2$, CO, and NO with $\rm C\sb2H\sb2,\ C\sb2H\sb4,\ C\sb3H\sb4,$ and $\rm C\sb4H\sb2)$ were measured using bolometric detection in a crossed-molecular beam apparatus. The observed ...
Chlorine dioxide photochemistry in solution: time-resolved resonance Raman and femtosecond pump-probe studies
The solution-phase reaction dynamics of chlorine dioxide (OClO) are studied using time-resolved resonance Raman (TRRR) and femtosecond pump-probe (FPP) spectroscopy. OClO photochemistry is investigated in a variety of solvents in order to ascertain the influence of environment on the photoreactivity of this compound. Specifically, ...
CE-microreactor-CE-MS-MS for protein analysis
Capillary electrophoresis-mass spectrometry (CE-MS) provides a powerful system that combines the speed and automation capabilities of CE with the detection and identification capabilities of MS. Integrating on-line enzymatic microreactor digestion with a CE-MS system reduces sample handling and allows fast digestions of small ...
Integrated theoretical and experimental studies of organic atmospheric aerosols
A combination of different projects are presented to (a) give the theoretical effects of organic aerosol on the nucleation and growth of cloud droplets and (b) present measurements of organic aerosol material at a land-based site used to study the remote marine atmosphere.The basis of the theoretical work is that organic ...
Molecular and nanoscale engineering for enhanced order in organic electro-optic materials
Intermolecular interactions play a critical role in organic electro-optic materials. Through careful molecular design and optimization, we explore the effect of these interactions on molecular properties, nanoscale acentric order, and ultimately macroscopic electro-optic activity. Discotic chromophores, designed to reduce ...
The biosynthesis of manumycin type metabolites
The biosynthesis of manumycin type metabolites has been thoroughly studied, mainly with the asukamycin producer, Streptomyces nodosus. A complete biosynthetic pathway has been elucidated from two approaches: (i) synthesizing and feeding labeled compounds to S. nodosus and the manumycin A producer, S. parvulus; (ii) tracing ...