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Copper-Catalyzed Reactions of Organoboron Compounds
The discovery, development, scope, and mechanistic studies of three new copper-catalyzed transformations of organoboron compounds are described herein. Specifically, Chapter 1 details the development and scope of the first general method for SN2'-selective substitution of primary allylic chlorides using aryl boronic esters ...
Label Transfer Reagents for the Investigation of Protein Kinase Complexes
Protein kinases are essential enzymes for cellular signaling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interactions with other signaling proteins. However, the weak and transient nature of ...
Enantioselective Diamination of Alkenes, Hydroamination of 1,3-Dienes, and the Development of NHC Palladium Complexes
Nitrogen containing heterocylces make up a vast majority of biologically relevant small molecules. Using transition metal catalysts to directly synthesize functionalized amine heterocycles is a valuable and efficient tool in chemical synthesis. Herein, the development of two palladium-catalyzed transformations are described; ...
Development of Palladium and Hypervalent Iodine(III) Catalyzed Alkene Difunctionalization Reactions; Hydroamination, Carboamination, Aminofluorination & Diamination
The investigation and development of synthetic methodologies for direct alkene difunctionalization is described. The utility of these processes is demonstrated by the synthesis of a number of functionalized nitrogen-containing heterocycles, including pyrrolidines and morpholines. As these are commonly-encountered motifs in a ...
Cross-Conjugated Moieties as Design Motifs for a Class of Novel Electro-Optic Chromophores
Organic electro-optic materials are at the forefront of current photonics applications that enable high speed data transmission, micro-scale sensors, and terahertz applications. Typically linearly conjugated push-pull type chromophores are the primary molecules of choice for various second and third order non-linear optical ...