Browsing Environmental health by Subject "Theses--Environmental health"
Now showing items 1-11 of 11
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Activation of glutamate-cysteine ligase in lymphocytes
(2000)Lymphocytes are normally quiescent cells that react to receptor-based signals by developing into functional effector cells that orchestrate immune responses. In their resting state, lymphocytes are highly susceptible to ... -
Cell cycle inhibition as a mode of abnormal development: the role of cell cycle checkpoint proteins and cyclin-dependent kinase inhibitors in neurodevelopmental toxicant defense
(2005)Neurodevelopment is an intensively complex process involving the production and organization of over a trillion cells into regions with specialized functions. Patterning of these structures is orchestrated via signaling ... -
Comparison of three methods of breath sampling for biological monitoring of volatile organic chemicals
(2004)This study compared three methods of breath sampling for assessment of exposure to volatile organic chemicals. Eleven healthy volunteers were exposed to four of these five chemicals: ethanol, acetone, methyl isobutyl ketone ... -
Developmental toxicity of alkylating agents in differentiating cell cultures
(1996)Alkylating agents are well known carcinogens and teratogens. Highest exposures occur in occupational settings, although other lifestyle factors also contribute to exposure. The four alkylating agents used in this study ... -
Differential response and susceptibility to oxidative stress in mouse lung fibroblasts heterozygous for phospholipid hydroperoxide glutathione peroxidase (GPx4)
(2006)Phospholipid hydroperoxide glutathione peroxidase (GPx4) is a member of the family of selenium dependent enzymes that catalyze the reduction of cell membrane-bound phospholipid hydroperoxides in situ and thus, protects ... -
Effects of ethanol on muscarinic receptor-induced responses in astroglia
(1999)A major and irreversible effect seen in the Fetal Alcohol Syndrome is microencephaly. The mechanism(s) underlying this effect remains unknown. Data from our laboratory demonstrate that ethanol inhibits muscarinic-induced ... -
Global positioning system (GPS) tracking to characterize children's exposure to pesticides
(2004)This dissertation documents the dynamic interaction between moving human receptors (children) and transient peaks in drifted pesticides proximal to treated fields. Validation of a novel dGPS instrument (the GPS Personal ... -
Identification and characterization of elements regulating the expression of the phenobarbital-inducible CYP2B1 and CYP2B2 genes
(1996)Phenobarbital (PB) is the prototype for a class of agents that produce marked induction in the genetic expression of a variety of metabolic enzymes in many species. One of the consequences of this induction is a change in ... -
Phenobarbital mediated induction of the cytochrome P450 2B genes: mechanistic investigations
(1998)The cytochrome P450 monooxygenases play a fascinating role as determinants of toxicity stemming from endogenous and foreign chemical exposure. In addition, certain natural and anthropogenic compounds, such as those present ... -
Respiratory infection control practices among healthcare workers in primary care and emergency department settings
(2006)This cross-sectional study used a self-administered questionnaire to survey healthcare workers (HCWs) at five medical centers, to evaluate reported use of CDC (Centers for Disease Control and Prevention) recommended ... -
Role of protein kinase C zeta in lipopolysaccharide-mediated nuclear factor kappa B aactivation [i.e. activation] and aactivity [i.e. activity] in kidney epithelial cells
(2006)NF-kappaB is a critical transcription factor that mediates cellular responses to invading pathogens. In the kidney, NF-kappaB's most important targets are the cytokines and chemokines, which regulate the scale of the ...