Epidemiology
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Recent Submissions
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Pathogenic Variant Status of High-Risk Genes, Polygenic, Epidemiological Risk Factors, and Utilization of Risk Management Options in Breast Cancer
Breast cancer is a heterogeneous disease with multiple established risk factors, which include high-penetrance germline variants in cancer predisposition genes such as ATM, BRCA1, BRCA2, CHEK2, and PALB2. Additionally, ... -
Phase 2 randomized open label adaptive platform clinical trial of the clinical and biological effects of IC14 treatment in patients with severe COVID-19
Background: In I-SPY COVID, a Phase 2 randomized open label adaptive platform clinical trial, we examined the clinical efficacy of the anti-CD14 monoclonal antibody IC14 for patients with severe COVID-19 requiring high-level ... -
INCIDENCE AND OUTCOMES OF LATE-ONSET RIGHT VENTRICULAR FAILURE IN PATIENTS WITH LEFT VENTRICULAR ASSIST DEVICE
Introduction: Right Ventricular Failure (RVF) is an incompletely understood complication observed in patients undergoing durable left ventricular assist device (LVAD) implantation. Prior research has primarily concentrated ... -
Health and economic impact of COVID-19, surveillance, and vaccination among people experiencing homelessness in Seattle-King County, Washington
The COVID-19 pandemic has disproportionately affected people experiencing homelessness, with shelters often representing a hotspot for outbreaks due to the elevated risk of viral transmission. COVID-19 surveillance in ... -
Adapting Trauma Outcome Prediction Models to Individual Facilities using Transfer Learning
With the increasing availability of big data and advanced computational techniques, machine learning (ML) models are becoming common in medicine and healthcare. Generalizable models, models that can be applied to any setting ... -
Cervical Cancer Screening Rates in Females Living with HIV at Three Healthcare Settings in the United States, 2010-2019
Females living with HIV (FLWHIV) are at greater risk of developing cervical cancer compared to females without HIV. National cervical cancer screening guidelines recommend more frequent screening for FLWHIV to address their ... -
Beverage consumption and perceived healthfulness among parents, and investigation of spillover effects: Insights from the Seattle Sweetened Beverage Tax
Sugar-sweetened beverage (SSB) taxes are generally adopted with the goal of reducing SSB consumption and improving public health. Extensive research on local SSB excise taxes in the US shows that taxes consistently increase ... -
Enhancing public health surveillance: integrating genomic and epidemiologic data to inform public health action and One Health progress
Pathogen genomic data can provide highly useful information for public health practice, particularly when combined and analyzed with epidemiologic data in real time. Likewise, a One Health approach pushes our current health ... -
Post-Diagnosis Statin Use and Survival Among Patients with Cancer
Statins are widely used cholesterol-lowering medications. Evidence from preclinical and observational studies suggest that statins use may improve cancer survival in patients with cancer, while findings from clinical trials ... -
Emergency Department Utilization and Unplanned Hospitalizations Associated with Floods in the US from 2008-2017: An Interrupted Time Series and Cohort Analysis
Background: Flooding is a major environmental hazard, with events increasing in intensity and frequency in the context of anthropogenic climate change. Significant health and economic impacts result from floods, particularly ... -
Suicide and Firearm Access among Legal System Involved Perpetrators of Domestic Violence
Individuals incarcerated for DV-related offenses or subject to domestic violence protection orders (DVPOs; i.e., respondents) have threatened or engaged in one form of violence perpetration and may be at increased risk for ... -
Improving the Efficiency and Effectiveness of Assisted Partner Services for HIV in Western Kenya
To control the HIV epidemic in Sub-Saharan Africa, it is crucial to increase the proportion of people who know their serostatus. In Kenya, approximately 1.6 million people are living with HIV (PLWH), of whom it is estimated ... -
Prevalence of Depressive Symptoms Among Children Exposed to Parental Incarceration in the 2019 and 2021 National Health Interview Survey (NHIS)
Background: Depression is a prevalent mental health disorder among 2.7 million (4.4%) children aged 3-17 in the United States (US), with adverse childhood experiences (ACEs) being a contributing factor. Parental incarceration ... -
KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Oncogenic mutations in KRAS codon 12 and codon 13 within exon 2 are frequently occurring mutations in colorectal cancer (CRC). However, the existing published data on the association of KRAS codon 12 and codon 13 mutations ... -
Polygenic risk scores and current exogenous estrogen use on the risk of venous thromboembolism in the Heart and Vascular Health Study: a case-only approach
Introduction: Venous thromboembolism (VTE) is a serious condition characterized by blood clot formation in veins. Exogenous hormone use is known to increase VTE risk, and understanding the interplay between genetic variants ... -
Predictors of Mortality and Discharge Location for Patients Supported by Venoarterial Extracorporeal Membrane Oxygenation
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a form of advanced life support that is increasingly used to treat cardiac or pulmonary failure, however morbidity and mortality for patients supported ... -
Exploring the online and in-person epidemiology and etiology of white supremacy
Racism, a common facet of white supremacy, is increasingly understood to be a major threat to both the health of democracy in the United States and to the public’s health. However, our understanding of white supremacy and ... -
NOVEL TESTING STRATEGIES TO SUPPORT HIV TREATMENT AND PREVENTION: ACCEPTABILITY, PREFERENCES, AND IMPACT ON ENGAGEMENT IN CARE AND SEXUAL BEHAVIORS
The primary goal of this dissertation project was to advance our understanding of the impact of novel testing strategies to support HIV treatment and prevention. Despite significant advancements in antiretroviral therapy ... -
Patterns of acute kidney injury and functional outcome scores in pediatric patients hospitalized with acute respiratory failure
BackgroundAcute kidney injury (AKI) is diagnosed in up to 30% of children admitted to pediatric intensive care units (PICU) and is strongly associated with morbidity and mortality. In recent years, there has been an increased ... -
Adverse pregnancy outcomes, non-retention, eligibility of differentiated care and virologic failure among women living with HIV in prevention of vertical transmission programs
Provision of antiretroviral treatment (ART) to women living with HIV (WLWH) before and during pregnancy is key to prevention of vertical HIV transmission (or prevention of mother-to-child transmission [PMTCT]), including ...