Browsing Epidemiology by Subject "Genetics"
Now showing items 1-17 of 17
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Association between Longitudinally Assessed Dietary Composition and Blood Telomere Length among Young Adult Filipinos
Diet and nutrition are known to play a pivotal role in the onset and progression of aging-related diseases, but it remains unclear how diet and nutrition influence aging processes in general. Telomeres, the nucleotide ... -
Diet, inflammation, and genetic predictors of tissue-specific gene expression: A functionally-informed gene-environment interaction analysis for risk of colorectal cancer.
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in both sexes combined worldwide, as well as the second leading cause of cancer deaths. Pathogenesis of CRC can be attributed to both genetic (G) and ... -
Factors associated with guideline-concordant biomarker testing in patients with stage IB-IIIA non-small cell lung cancer
Background: Even with recent advances in identifying oncogenic genomic alterations and developing targeted therapies for non-small cell lung cancer (NSCLC), the uptake of molecular testing remains suboptimal among patients ... -
Finding the Association between BMI and Risk of Subsequent Primary Cancer of the Breast, Lung, Colon, and Endometrium among Breast Cancer Survivors
IntroductionThere is a large population of breast cancer survivors at risk of developing second primary cancers. Most previous studies of second cancers have utilized data from cancer registries or medical records, with ... -
Genetic variation in telomere maintenance genes and survival after colorectal cancer diagnosis
Introduction: Telomeres are the repetitive nucleotide sequences capping the end of chromosomes and are regulated by telomerase. Both telomere length and telomerase initiate carcinogenesis and prognosis in patients diagnosed ... -
Genetic Variations and Risk of Placental Abruption
Background: Placental abruption (PA) is a premature separation of an implanted placenta due to the rupture of the maternal vessels in the decidua basalis prior to delivery of the fetus. PA complicates approximately 1 in ... -
Genetics, Mammographic Density and Breast Cancer Risk
Mammographic, or breast density, describing breast tissue composition, is one of the strongest risk factors for breast cancer, the most common cancer type among women in the US. In general, women in the highest breast ... -
Genomic epidemiology on the frontline: Inferring disease dynamics from pathogen genomes and supporting genomic analysis in applied public health settings.
Within infectious disease epidemiology, genomic epidemiology is a field that seeks to describe pathogen transmission dynamics using evolutionary analysis of pathogen genome sequences and associated metadata. Genomic data ... -
Intergenerational Transmission of Health Inequities: Early Life Socioeconomic Factors, Adult Cardiometabolic and Pregnancy Outcomes, and Potential Epigenetic Mechanisms in Young Adult Women.
Parental socioeconomic status (SES) experienced by a woman in utero may directly affect her adult health, independent of her life course experiences. Developmental programming of gene expression through DNA methylation may ... -
Pathogenic Variant Status of High-Risk Genes, Polygenic, Epidemiological Risk Factors, and Utilization of Risk Management Options in Breast Cancer
Breast cancer is a heterogeneous disease with multiple established risk factors, which include high-penetrance germline variants in cancer predisposition genes such as ATM, BRCA1, BRCA2, CHEK2, and PALB2. Additionally, ... -
Pharmacogenetic determinants of calcineurin inhibitor associated nephrotoxicity in liver transplant patients
(2013-11-14)The use of calcineurin inhibitors (tacrolimus and cyclosporine) has become standard of care in post-transplant immunosuppression. While these medications have greatly reduced organ rejection, they can cause nephrotoxicity ... -
Polygenic risk scores and current exogenous estrogen use on the risk of venous thromboembolism in the Heart and Vascular Health Study: a case-only approach
Introduction: Venous thromboembolism (VTE) is a serious condition characterized by blood clot formation in veins. Exogenous hormone use is known to increase VTE risk, and understanding the interplay between genetic variants ... -
Race, ethnicity, and melanocortin-1-receptor polymorphisms are associated with post-burn hypertrophic scarring: a prospective cohort study
Objective: To assess the association between melanocortin 1 receptor (MC1R) single-nucleotide polymorphisms (SNPs) and severity of post-burn hypertrophic scarring (HTS). Background: People of color seem predisposed to HTS, ... -
The genetics of sex hormones and their effects on mammographic density in women
In this work we leveraged genomic information from large-scale population-based studies to explore the relationships between three epidemiologic factors associated with breast cancer in women: 1) mammographic density, 2) ... -
The Mutational Landscape of Recurrent vs Non-Recurrent Human Papillomavirus-Associated Oropharyngeal Cancer
Current therapies are effective for a subset of human papillomavirus (HPV)-associated head and neck cancers (HNC), although up to a quarter of these cases fail treatment. Identification of genomic alterations associated ... -
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women
(2013-07-25)Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although ... -
Utility of Next-Generation Sequencing for HIV Antiretroviral Resistance Genotyping in a Pragmatic Clinical Laboratory Setting
Routine HIV antiviral resistance genotyping is an important tool in the clinical management of HIV infections and interest is growing among clinical laboratories for the use of next-generation sequencing (NGS) in HIV drug ...