Browsing Immunology by Issue Date
Now showing items 1-20 of 39
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The role of the cytoplasmic tail of antigen-presenting cell surface molecule CD80 in delivery of T cell costimulation
(1997)CD80 is a highly glycosylated surface protein of 45-60 kDa found on activated B cells, T cells, monocytes, and dendritic cells. Based upon the CD80 cDNA sequence, the molecular weight of the protein core is 30 kDa. The ... -
Random subcloning, pairwise end sequencing, and the molecular evolution of the vertebrate trypsinogens
(1998)Mathematical theory for random subcloning is presented and discussed in detail. The pairwise end sequencing strategy for mapping and sequencing is presented in a general form; specific examples are analyzed with the aid ... -
Tuning Notch signals in T cell development
(2005)In this study, I have attempted to understand how Notch signals promote different stages of T cell maturation by examining the regulation of Notch signals on two levels. First, I have used an in vitro culture system to ... -
Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8p+s T cells for adoptive immunotherapy of cancer
(2006)Adoptive T cell immunotherapy has shown promise in treating some cancers, but the challenge of isolating T cells with high avidity for tumor antigens limits large-scale applicability. T cell receptor (TCR) gene transfer ... -
CD4+ Foxp3+ regulatory T cell homing & homeostasis
(2007)CD4+Foxp3+ T cells (TR) are essential for maintaining self-tolerance, but their sites of action in vivo and homeostatic mechanisms are poorly defined. I examined homing receptor (HR) expression by TR in the steady state ... -
Beta2 Integrins Inhibit TLR Responses by Reducing NF-kappaB Pathway Activation
(2012-09-13)Although originally considered to be the archetypal cell activation pathway, signals through immunoreceptor tyrosine-based activation motifs (ITAM) are known to be inhibitory and have recently been appreciated to cross-regulate ... -
Targeting a self/tumor antigen expressed in the prostate for adoptive T cell immunotherapy of prostate cancer
(2013-02-25)Adoptive T cell therapy (ACT) for the treatment of established cancers is actively being pursued in clinical trials. However, poor in vivo persistence and maintenance of anti-tumor activity of transferred tumor-specific T ... -
Nucleic Acid Detection in Anti-Viral Responses and Autoimmunity
(2013-04-17)Viruses infect all living organisms. Therefore, hosts evolved extensive means to detect and destroy viral pathogens. Pattern recognition receptors that detect viral RNA or DNA genome are important components of the innate ... -
The role of CD22 and Bim expression as determinants for the regulation of antigen-specific adaptive immune responses
(2013-04-17)University of Washington Abstract The role of CD22 and Bim expression as determinants for the regulation of antigen-specific adaptive immune responses Daphne Yin-Wai Ma Chair of the Supervisory Committee: Professor Edward ... -
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases for genome engineering applications
(2013-04-17)Although engineered LAGLIDADG homing endonucleases (LHEs) are finding increasing applications in biotechnology, their generation remains a challenging, industrial-scale process. As new single-chain LAGLIDADG nuclease ... -
The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
(2013-07-23)The epithelially-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that ... -
Tim-3 regulation of central nervous system autoimmune disease
(2013-07-23)Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) mediated by self-reactive, myelin-specific T cells. Both CD4+ and CD8+ T cells play important roles in the pathogenesis ... -
Signals Controlling Peripheral B Cell Development, Selection, and Activation
(2013-07-25)Control of B cell development through transitional stages in the periphery is critical for the proper maintenance and selection of mature, functional B cell subsets capable of mediating humoral immunity. We have established ... -
Mechanism of hepatic inflammation during hepatitis C virus infection
(2013-11-14)Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer, but the processes that promote hepatic inflammation by HCV ... -
Mechanisms of interferon-α inhibition by intravenous immunoglobulin
(2013-11-14)Several lines of evidence implicate type I interferons (IFN-I, including IFN-α and IFN-β) in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are specialized in the production ... -
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
(2014-02-24)Virus recognition and response by the innate immune system are critical components of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus ... -
Pre-programmed regulatory networks and poised chromatin potentiate lineage-specific differentiation of CD4+ T cells
(2014-02-24)How the interactions of transcription factors (TFs) with specific regions of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which ... -
Control of Foxp3+ regulatory T cell abundance and function by distinct signals in different immune environments
(2014-02-24)Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3+ regulatory T (Treg) cells. The importance of interleukin (IL)-2 in immune tolerance is demonstrated by the ... -
Genome engineering to expand applications of human T-cell immunotherapy
Adoptive T-cell therapy, particularly chimeric antigen receptor (CAR) therapy, is a revolutionary and quickly-evolving means of treating cancer patients who can no longer be helped by standard therapies. In multiple ... -
BCR and co-receptor crosstalk regulates B cell positive selection in autoimmunity
A common genetic variant in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22-C1858T) has been linked to a wide range of autoimmune disorders. Although a B cell-intrinsic role in promoting ...