Browsing Immunology by Issue Date

Now showing items 1-20 of 26

The role of the cytoplasmic tail of antigen-presenting cell surface molecule CD80 in delivery of T cell costimulation

Doty, Raymond Thomas, 1966- (1997)

CD80 is a highly glycosylated surface protein of 45-60 kDa found on activated B cells, T cells, monocytes, and dendritic cells. Based upon the CD80 cDNA sequence, the molecular weight of the protein core is 30 kDa. The ...
Random subcloning, pairwise end sequencing, and the molecular evolution of the vertebrate trypsinogens

Roach, Jared C (1998)

Mathematical theory for random subcloning is presented and discussed in detail. The pairwise end sequencing strategy for mapping and sequencing is presented in a general form; specific examples are analyzed with the aid ...
Tuning Notch signals in T cell development

Lehar, Sophie M (2005)

In this study, I have attempted to understand how Notch signals promote different stages of T cell maturation by examining the regulation of Notch signals on two levels. First, I have used an in vitro culture system to ...
Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8p+s T cells for adoptive immunotherapy of cancer

Dossett, Michelle Leigh (2006)

Adoptive T cell immunotherapy has shown promise in treating some cancers, but the challenge of isolating T cells with high avidity for tumor antigens limits large-scale applicability. T cell receptor (TCR) gene transfer ...
CD4+ Foxp3+ regulatory T cell homing & homeostasis

Sather, Blythe Duke (2007)

CD4+Foxp3+ T cells (TR) are essential for maintaining self-tolerance, but their sites of action in vivo and homeostatic mechanisms are poorly defined. I examined homing receptor (HR) expression by TR in the steady state ...
Beta2 Integrins Inhibit TLR Responses by Reducing NF-kappaB Pathway Activation

Yee, Nathan Ken (2012-09-13)

Although originally considered to be the archetypal cell activation pathway, signals through immunoreceptor tyrosine-based activation motifs (ITAM) are known to be inhibitory and have recently been appreciated to cross-regulate ...
Targeting a self/tumor antigen expressed in the prostate for adoptive T cell immunotherapy of prostate cancer

Chou, Cassie K (2013-02-25)

Adoptive T cell therapy (ACT) for the treatment of established cancers is actively being pursued in clinical trials. However, poor in vivo persistence and maintenance of anti-tumor activity of transferred tumor-specific T ...
Nucleic Acid Detection in Anti-Viral Responses and Autoimmunity

Brunette, Rebecca Lynn (2013-04-17)

Viruses infect all living organisms. Therefore, hosts evolved extensive means to detect and destroy viral pathogens. Pattern recognition receptors that detect viral RNA or DNA genome are important components of the innate ...
The role of CD22 and Bim expression as determinants for the regulation of antigen-specific adaptive immune responses

Ma, Daphne Yin-Wai (2013-04-17)

University of Washington Abstract The role of CD22 and Bim expression as determinants for the regulation of antigen-specific adaptive immune responses Daphne Yin-Wai Ma Chair of the Supervisory Committee: Professor Edward ...
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases for genome engineering applications

Baxter, Sarah Katherine (2013-04-17)

Although engineered LAGLIDADG homing endonucleases (LHEs) are finding increasing applications in biotechnology, their generation remains a challenging, industrial-scale process. As new single-chain LAGLIDADG nuclease ...
The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium

Miazgowicz, Michael Miles (2013-07-23)

The epithelially-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that ...
Tim-3 regulation of central nervous system autoimmune disease

Lee, Sarah Y. (2013-07-23)

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) mediated by self-reactive, myelin-specific T cells. Both CD4+ and CD8+ T cells play important roles in the pathogenesis ...
Signals Controlling Peripheral B Cell Development, Selection, and Activation

Schwartz, Marc (2013-07-25)

Control of B cell development through transitional stages in the periphery is critical for the proper maintenance and selection of mature, functional B cell subsets capable of mediating humoral immunity. We have established ...
Mechanism of hepatic inflammation during hepatitis C virus infection

Negash, Amina Abduletif (2013-11-14)

Chronic hepatitis C virus (HCV) infection is a leading cause of liver disease. Liver inflammation underlies infection-induced fibrosis, cirrhosis and liver cancer, but the processes that promote hepatic inflammation by HCV ...
Mechanisms of interferon-α inhibition by intravenous immunoglobulin

Wiedeman, Alice Emily (2013-11-14)

Several lines of evidence implicate type I interferons (IFN-I, including IFN-α and IFN-β) in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are specialized in the production ...
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection

Errett, John Stephen (2014-02-24)

Virus recognition and response by the innate immune system are critical components of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus ...
Pre-programmed regulatory networks and poised chromatin potentiate lineage-specific differentiation of CD4+ T cells

Raubitschek, Antony C. (2014-02-24)

How the interactions of transcription factors (TFs) with specific regions of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which ...
Control of Foxp3+ regulatory T cell abundance and function by distinct signals in different immune environments

Smigiel, Kate (2014-02-24)

Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3+ regulatory T (Treg) cells. The importance of interleukin (IL)-2 in immune tolerance is demonstrated by the ...
Type I Interferons Negatively Regulate Foxp3+ Regulatory T Cells during Acute Viral Infection and Autoimmunity

Srivastava, Shivani

CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are potent anti- inflammatory cells capable of restraining immune responses to both self- and foreign-antigens. In addition to preventing autoimmunity ...
Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis

Moguche, Albanus O.

Tuberculosis (TB) is a chronic pulmonary disease caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb). Even though CD4 T cells are critical for containing Mtb, the immune system rarely eradicates the ...

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