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The role of the cytoplasmic tail of antigen-presenting cell surface molecule CD80 in delivery of T cell costimulation
(1997)
CD80 is a highly glycosylated surface protein of 45-60 kDa found on activated B cells, T cells, monocytes, and dendritic cells. Based upon the CD80 cDNA sequence, the molecular weight of the protein core is 30 kDa. The remaining 15-30 kDa of the molecular weight is N-linked carbohydrate attached at eight possible sites in the ...
CD4+ Foxp3+ regulatory T cell homing & homeostasis
(2007)
CD4+Foxp3+ T cells (TR) are essential for maintaining self-tolerance, but their sites of action in vivo and homeostatic mechanisms are poorly defined. I examined homing receptor (HR) expression by TR in the steady state and determined whether altering TR distribution by removal of CCR4 impairs their ability to maintain ...
Tuning Notch signals in T cell development
(2005)
In this study, I have attempted to understand how Notch signals promote different stages of T cell maturation by examining the regulation of Notch signals on two levels. First, I have used an in vitro culture system to examine how differential signals through 2 classes of Notch ligands, Jagged and Delta, influence thymocyte ...
Generation and expression of high affinity, tumor antigen-specific mouse and human T cell receptors to genetically modify CD8p+s T cells for adoptive immunotherapy of cancer
(2006)
Adoptive T cell immunotherapy has shown promise in treating some cancers, but the challenge of isolating T cells with high avidity for tumor antigens limits large-scale applicability. T cell receptor (TCR) gene transfer employing high affinity TCRs recognizing defined tumor-associated antigens can potentially circumvent these ...
Random subcloning, pairwise end sequencing, and the molecular evolution of the vertebrate trypsinogens
(1998)
Mathematical theory for random subcloning is presented and discussed in detail. The pairwise end sequencing strategy for mapping and sequencing is presented in a general form; specific examples are analyzed with the aid of computer simulations. The evolution of the vertebrate trypsinogen multigene family is discussed in the ...