The system be down for regular maintenance on April 3rd, 2024 from 8:00-10:00am.
Browsing Medicinal chemistry by Title
Now showing items 35-54 of 54
-
Ligand and Protein Dynamics of CYP3A4
Cytochrome P450 3A4 (CYP3A4) dominates drug metabolism in humans. Examples of promiscuity (binding and catalytic) and allosterism in CYP3A4 are ubiquitous but poorly understood. This work is dedicated to improving our ... -
Lipid Peroxidation Mechanisms and Their Contribution to Ferroptosis
The attack of reactive oxygen species (ROS) on reactive lipids leads to free radical chain reactions with molecular oxygen, a process termed lipid peroxidation. Increased lipid peroxidation is associated with many human ... -
Mechanisms of antibody-mediated neutralization targeting viral glycoproteins
The antibody response against viral glycoproteins is important for preventing many viral infections but we lack a comprehensive understanding of the mechanisms by which antibodies act. Furthermore, the immense antigenic ... -
Mechanisms of oxidation of acetaminophen
(1984)The metabolism of drugs and other xenobiotics normally expediates elimination and detoxification. However, in some instances inert compounds are transformed into potent alkylating or arylating agents capable of eliciting ... -
Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines
(2003)The mechanism of CYP1A2 (cytochrome P450 1A2) catalyzed metabolism of 8-alkylxanthines is explored using deuterium isotope effect studies and isotope tracing experiments with an 8-isopropyl analog (isopropylcyclohexylline, ... -
METTL7 Alkyl Thiol Methyltransferases: Implications in Drug Metabolism and Human Health
Thiol metabolism in humans is catalyzed by two enzymes, thiopurine methyltransferase (TPMT) and thiol methyltransferase (TMT). TPMT selectively methylates thiopurine compound while TMT is selective for aliphatic thiol ... -
Non-Dissociative Sequential Metabolism of Enoxacin to a Metabolic Intermediate Complex with Cytochrome P450 1A2
Cytochrome P450 enzymes constitute a superfamily of isoforms which accelerate the removal of foreign compounds from the body through oxidative biotransformation to generate polar metabolites that are more readily excreted ... -
Pushing the limits of Structural Mass Spectrometry to Characterize the Viral Packaging Motor
Assessing protein structure is a difficult undertaking, yet is often required for a complete mechanistic understand of how a protein functions. The traditional techniques used to assess protein structure are X-ray ... -
Role of Epoxyeicosatrienoic Acids in Protecting Against Ischemic Cardiomyopathy
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid (AA) epoxidation with important cardioprotective and signaling properties. AA is a twenty carbon ω-6 polyunsaturated fatty acid containing four cis-double ... -
Searching for Protein Biomarkers of Disease in Bronchoalveolar Lavage Fluid
(2013-04-17)Respiratory diseases minimize gas exchange at the alveoli and complicate the mechanics of breathing. Bronchoalveolar lavage fluid (BALF) is capable of sampling the components of the alveolar epithelial lining fluid (ELF) ... -
Selectivity and Mechanisms of Human Cytochrome P450 Inhibition by Chlormethiazole
The cytochrome P450 (CYP) superfamily of enzymes are heme containing enzymes that primarily perform oxidative reactions to a variety of substrates, including small molecule drugs and other xenobiotics. Formation of polar ... -
Species Differences in the Metabolism and Toxicity of 4-Ipomeanol
(2013-04-17)The studies presented in this dissertation investigate the enzymatic basis for the species differences in target organ toxicity of the pro-toxin, 4-ipomeanol (IPO). <italic>In vitro</italic> studies that monitored the ... -
Structural Dynamics and Reaction Reversibility of Specific vs. Promiscuous Detoxification Enzymes
Detoxification enzymes occupy a unique niche in biology. Unlike most enzymes with defined roles in biochemical pathways, detoxification enzymes have evolved to bind and metabolize many chemically unrelated structures ¬– ... -
Structural immunology of humoral and cellular recognition of a MUC1 breast cancer antigen
(2003)MUC1 mucins have recently been the target of breast cancer vaccine trials. MUC1 peptide vaccine studies in mice have resulted in rejection of solid tumor and protection from further tumor challenge. These results represent ... -
Structural Insights into Viral Membrane Fusion Machinery via Cryo-Electron Tomography: Influenza Virus and Human Parainfluenza Virus
Enveloped viruses such as influenza virus and human parainfluenza virus utilize specialized protein machinery to fuse their membrane with the cellular membrane of target host cells and thus deliver their genome for ... -
Structural Mechanics of Class 1 Viral Membrane Fusion Proteins
Protein-mediated membrane fusion is a highly regulated biological process essential for cellular and organismal functions and infection by enveloped viruses. During viral entry, the membrane fusion reaction is catalyzed ... -
Temporal and Spatial Multi-omics Characterization of Smith-Lemli-Opitz Syndrome
Smith-Lemli-Opitz syndrome (SLOS) is a metabolic disorder caused by genetic mutations in the DHCR7 gene, leading to defective 3β-hydroxysterol-Δ7-reductase (DHCR7), the enzyme that catalyzes the last step of cholesterol ... -
The Impact of Nonideality on the Biophysical Properties of Therapeutic Antibodies in Physiological Environments
Antibody-based therapeutics are some of the best-selling drugs on the market with indications in several aggressive cancers, chronic autoimmune conditions, and other disease states. They provide several advantages over ... -
The Rational Discovery and Development of Disordered Protein Ligands
Intrinsically disordered proteins play vital roles in biology and their dysfunction contributes to many major disease states, making them appealing pharmacological targets. These proteins are challenging targets for rational ... -
Thermodynamic and Directed Physical Characterization of Bacteriophage Lambda Capsid Maturation
All viruses undergo a multistep developmental process to assemble a mature virus. An essential step in the assembly of complex double-stranded DNA viruses is packaging the viral genome into a pre-formed procapsid shell. ...