Browsing Medicinal chemistry by Title
Now showing items 22-30 of 30
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Mechanisms of oxidation of acetaminophen
(1984)The metabolism of drugs and other xenobiotics normally expediates elimination and detoxification. However, in some instances inert compounds are transformed into potent alkylating or arylating agents capable of eliciting ... -
Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines
(2003)The mechanism of CYP1A2 (cytochrome P450 1A2) catalyzed metabolism of 8-alkylxanthines is explored using deuterium isotope effect studies and isotope tracing experiments with an 8-isopropyl analog (isopropylcyclohexylline, ... -
Non-Dissociative Sequential Metabolism of Enoxacin to a Metabolic Intermediate Complex with Cytochrome P450 1A2
Cytochrome P450 enzymes constitute a superfamily of isoforms which accelerate the removal of foreign compounds from the body through oxidative biotransformation to generate polar metabolites that are more readily excreted ... -
Pushing the limits of Structural Mass Spectrometry to Characterize the Viral Packaging Motor
Assessing protein structure is a difficult undertaking, yet is often required for a complete mechanistic understand of how a protein functions. The traditional techniques used to assess protein structure are X-ray ... -
Searching for Protein Biomarkers of Disease in Bronchoalveolar Lavage Fluid
(2013-04-17)Respiratory diseases minimize gas exchange at the alveoli and complicate the mechanics of breathing. Bronchoalveolar lavage fluid (BALF) is capable of sampling the components of the alveolar epithelial lining fluid (ELF) ... -
Species Differences in the Metabolism and Toxicity of 4-Ipomeanol
(2013-04-17)The studies presented in this dissertation investigate the enzymatic basis for the species differences in target organ toxicity of the pro-toxin, 4-ipomeanol (IPO). <italic>In vitro</italic> studies that monitored the ... -
Structural immunology of humoral and cellular recognition of a MUC1 breast cancer antigen
(2003)MUC1 mucins have recently been the target of breast cancer vaccine trials. MUC1 peptide vaccine studies in mice have resulted in rejection of solid tumor and protection from further tumor challenge. These results represent ... -
Structural Insights into Viral Membrane Fusion Machinery via Cryo-Electron Tomography: Influenza Virus and Human Parainfluenza Virus
Enveloped viruses such as influenza virus and human parainfluenza virus utilize specialized protein machinery to fuse their membrane with the cellular membrane of target host cells and thus deliver their genome for ... -
Thermodynamic and Directed Physical Characterization of Bacteriophage Lambda Capsid Maturation
All viruses undergo a multistep developmental process to assemble a mature virus. An essential step in the assembly of complex double-stranded DNA viruses is packaging the viral genome into a pre-formed procapsid shell. ...