Browsing Medicinal chemistry by Subject "Medicinal chemistry"
Now showing items 1-5 of 5
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Biochemical and Mechanistic Studies of the Interactions Between Vitamin K Antagonists and Vitamin K Epoxide Reductase
(2013-02-25)The studies that are presented in this dissertation have; (i) established a mechanism by which warfarin dose response is modulated by VKORC1 genotype under optimized conditions for kinetic analysis of human vitamin K epoxide ... -
Biophysical and Structural Approaches to Characterize the Mechanism of P-glycoprotein, a Multidrug Efflux Transporter
P-glycoprotein (P-gp), an ATP Binding Cassette transporter (ABCB1), plays an important role in multidrug resistance in cancers and clinical drug interactions. P-gp utilizes the energy from ATP hydrolysis to drive conformational ... -
Conformational Heterogeneity and Catalytic Promiscuity in Glutathione Transferases
(2013-02-25)Enzymological paradigms have shifted recently to acknowledge the biological importance of catalytic promiscuity. Detoxification enzymes, such as glutathione transferases, are known to be highly promiscuous. One common ... -
Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms
(2012-09-13)Cytochrome b5 (cyt b5 or holo b5) is known as one of the key components in the microsomal cytochrome P450 (CYP) monooxygenase system that metabolizes structurally diverse endogenous and exogenous compounds. It has been ... -
Non-Dissociative Sequential Metabolism of Enoxacin to a Metabolic Intermediate Complex with Cytochrome P450 1A2
Cytochrome P450 enzymes constitute a superfamily of isoforms which accelerate the removal of foreign compounds from the body through oxidative biotransformation to generate polar metabolites that are more readily excreted ...