Browsing Medicinal chemistry by Subject "Medicinal chemistry"
Now showing items 1-3 of 3
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Biochemical and Mechanistic Studies of the Interactions Between Vitamin K Antagonists and Vitamin K Epoxide Reductase
(2013-02-25)The studies that are presented in this dissertation have; (i) established a mechanism by which warfarin dose response is modulated by VKORC1 genotype under optimized conditions for kinetic analysis of human vitamin K epoxide ... -
Conformational Heterogeneity and Catalytic Promiscuity in Glutathione Transferases
(2013-02-25)Enzymological paradigms have shifted recently to acknowledge the biological importance of catalytic promiscuity. Detoxification enzymes, such as glutathione transferases, are known to be highly promiscuous. One common ... -
Investigation of Surface Interactions between Cytochrome b5 and Major Cytochrome P450 Isoforms
(2012-09-13)Cytochrome b5 (cyt b5 or holo b5) is known as one of the key components in the microsomal cytochrome P450 (CYP) monooxygenase system that metabolizes structurally diverse endogenous and exogenous compounds. It has been ...