Browsing Microbiology by Issue Date
Now showing items 1-20 of 66
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Taxonomy, biogeography, and evolution of polar gas vacuolate bacteria
(1996)Over 250 gas vesicle producing (gas vacuolate) bacteria have been isolated from arctic and antarctic sea ice and water (Irgens et al., 1989; Staley et al., 1989; Gosink et al., 1993; Gosink and Staley, 1995). These strains ... -
Regulation of the flagellar specific sigma factor, sigma28, of Salmonella typhimurium by the anti-sigma factor FlgM
(1998)Expression of the flagellar genes of Salmonella typhimurium occurs in an ordered hierarchy that is coupled to the morphogenesis of the flagellar organelle. Transcription of the late (Class 3) flagellar genes is dependent ... -
The interferon induced serine/threonine protein kinase, PKR, is regulated by the influenza virus activated protein, P58IPK, and the molecular chaperones, Hsp40 and Hsp70
(1998)P58IPK is a TPR-containing protein with homology to the J-domain of DnaJ. P58IPK was first recognized for its ability to inhibit the interferon-induced double-stranded RNA-activated serine/threonine protein kinase, PKR, ... -
Regulation of protein synthesis and induction of oncogenesis by a cellular protein kinase inhibitor
(1998)P58IPK is a cellular inhibitor of the interferon-induced, dsRNA-activated, serine/threonine kinase, PKR. Earlier, P58IPK was shown to block both PKR autophosphorylation and the phosphorylation of eIF-2alpha substrate in ... -
The mechanisms of Pol expression and assembly for human foamy virus
(1999)In this study, I have examined the role of Pol in the replication pathway of HFV. We discovered that unlike all known retroviruses, the Pol protein is expressed independently of Gag from a spliced mRNA, rather than as a ... -
Population genetics of human immunodeficiency virus type 1 during within-host chronic infection
(2003)Human immunodeficiency virus type 1 (HIV-1) has high replication and mutation rates that generate large census populations and high levels of genetic variation. Furthermore, there is now widespread global circulation of ... -
Formaldehyde metabolism in Methylobacterium extorquens AM1
(2003)Methylotrophic bacteria are capable of growth on single-carbon compounds as their sole source of carbon and energy. This metabolism entails the production of formaldehyde as a central intermediate. Methylobacterium extorquens ... -
Host responses to Salmonella typhimurium infection in vitro and in vivo
(2003)Salmonella spp. are facultative intracellular pathogens capable of causing localized and systemic disease of significant morbidity and mortality; disease can be prevented by oral immunization with viable attenuated bacteria. ... -
Identification of factors involved in processing of mRNA in a fimbrial operon of Escherichia coli
(2004)Endonucleolytic cleavage of mRNA in the daa operon of Escherichia coli is responsible for coordinate regulation of genes involved in F1845 fimbrial biogenesis. Cleavage occurs by an unidentified endoribonuclease and ... -
Fundamentals of the Host-Virus Evolutionary Arms Race
(2012-08-10)The immune system has been battling viral infections over the course of millions of years in primate evolution. The constant evolution of hosts and viruses to defeat the other has led to a high stakes genetic arms race. ... -
Extracellular Polysaccharides in Pseudomonas aeruginosa
(2012-09-13)Biofilms are a prominent mode of bacterial growth in the environment and in disease. Biofilm development involves specific stages including surface adherence, proliferation, cell-cell cohesion and dispersion. Each of these ... -
Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
(2012-09-13)A major roadblock in the global eradication of tuberculosis lies in the long duration of treatment required for cure. This well documented need for long-term therapy is historically attributed to the infecting mycobacteria ... -
Posttranslational mechanisms of nitrogenase regulation in Rhodopseudomonas palustris CGA009
(2012-09-13)Nitrogenase catalyzes the conversion of dinitrogen gas (N2) and protons to ammonia and hydrogen gas (H2). This is a catalytically difficult reaction that requires large amounts of ATP and reducing power. Thus, nitrogenase ... -
Activation of the Salmonella enterica serovar Typhimurium translocated glycerophospholipid:cholesterol acyltransferase SseJ by the small GTPase RhoA
(2013-02-25)<italic>Salmonella enterica</italic> serovar Typhimurium translocates a glycerophospholipid:cholesterol acyltransferase (SseJ) into the host cytosol after its entry into mammalian cells. SseJ is recruited to the cytoplasmic ... -
The function and diversity of the antiretroviral restriction factors TRIM5alpha and TRIMCyp in Old World primates
(2013-02-25)The retroviral restriction factors TRIM5α and TRIMCyp, encoded in the <italic>TRIM5</italic> gene, prevent cross-species transmission of retroviruses in primates. In macaques (genus <italic>Macaca</italic>), TRIMCyp evolved ... -
The cyclic-di-GMP receptors of S. Typhimurium: testing their signaling specificity through second messenger affinity and their use as biosensors
(2013-04-17)c-di-GMP is a second messenger that regulates motility and the production of adhesive factors in many bacterial species. Enzymes containing specific c-di-GMP metabolizing domains integrate information about the environment ... -
Mechanisms of inflammasome activation and inhibition during Yersinia infection
(2013-04-17)The host inflammatory response is strikingly delayed during the initial stages of infection with Yersinia pestis and Y. pseudotuberculosis, pathogens that can suppress immune defenses. This work identifies the bacterial ... -
Oral Polymicrobial Communities in Health and Disease
(2013-07-23)The oral microbial community represents the best-characterized consortium associated with the human host. There are strong correlations between the qualitative composition of the oral microbiota and clinically healthy or ... -
Function, localization and regulation of the Pseudomonas aeruginosa diguanylate cyclase response regulator WspR
(2013-07-25)WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of <italic>Pseudomonas aeruginosa</italic> on surfaces. Active WspR produces ... -
Latent Kaposi's Sarcoma Herpesvirus regulates host factors to induce Lymphangiogenesis and Angiogenesis
(2013-07-25)Kaposi's Sarcoma herpesvirus (KSHV), the etiologic agent of Kaposi's Sarcoma, is present in the predominant tumor cells of KS, the spindle cells. Spindle cells express markers of lymphatic endothelium and, interestingly, ...