The system will be down for regular maintenance from 8:00-10:00am PDT on April 3rd, 2024.
Browsing Microbiology by Subject "Immunology"
Now showing items 1-12 of 12
-
Dissecting the Multifaceted Antibody Response to Influenza A Virus and Severe Acute Respiratory Syndrome Coronavirus 2
Antibodies are the first line of defense against invading respiratory pathogens, and their effectiveness at preventing infection and disease depends heavily on what antigens are targeted. For both influenza A virus and ... -
Essential Role of Protein Kinase R Antagonism by TRS1 in Human Cytomegalovirus Replication
Human cytomegalovirus (HCMV) lacking TRS1 and IRS1 (HCMV[ΔI/ΔT]) cannot replicate in cell culture. Although both proteins can block the protein kinase R (PKR) pathway, they have been reported to have multiple other activities ... -
Higher HIV-1 Env gp120-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Is Associated with Lower Levels of Defective HIV-1 Provirus
During HIV-1 (HIV) infection, continued administration of antiretroviral therapy (ART) can decrease a person’s viral load to undetectable levels and allow for a near-normal lifespan, though ART is not a cure due to a ... -
Host-defense peptides enhance enteric viral infection in a small intestinal organoid model and in vivo
The human small intestinal epithelium is a physical barrier to microbes, but it also produces numerous proteins and peptides that form a chemical barrier to infection. The most abundant of these peptides are the enteric ... -
Influenza vaccines and antivirals that target the conserved hemagglutinin stem
Influenza is a major public health threat, and pandemics, such as the 2009 H1N1 outbreak, are inevitable. Due to low efficacy of seasonal flu vaccines and the increase in drug-resistant strains of influenza viruses, there ... -
Insights into alpha-defensin modulation of non-enveloped viral infection
Alpha-defensins are small antimicrobial peptides that play a crucial role in innate immunity across various mammalian species. Possessing broad antimicrobial properties, they have neutralizing activity against bacteria and ... -
Mechanisms of inflammasome activation and inhibition during Yersinia infection
(2013-04-17)The host inflammatory response is strikingly delayed during the initial stages of infection with Yersinia pestis and Y. pseudotuberculosis, pathogens that can suppress immune defenses. This work identifies the bacterial ... -
Mechanisms of negative regulation of inflammasome activation
Pyroptosis is an inflammatory program of cell death that is coordinated by the assembly of macromolecular structures known as inflammasomes. Pathogenic Yersinia species have evolved specific mechanisms to inhibit inflammasome ... -
STING is dispensable during KSHV infection of primary endothelial cells
Viruses are obligate intracellular parasites requiring host cells to replicate and spread. To prevent this, cells utilize a variety of protein receptors in order to surveil for invading viruses, with detection resulting ... -
STING is required in conventional dendritic cells for DNA vaccine induction of type I T helper cell-dependent antibody responses
DNA vaccines elicit antibody, T helper cell, CD8+ T cell, and cytotoxic T lymphocyte (CTL) responses. Currently, little is known about the mechanism that DNA vaccines employ to induce adaptive immune responses. Studies ... -
Therapeutic conserved elements (CE) DNA vaccines in simian-human immunodeficiency virus (SHIV) or SIV-infected macaques
Antiretroviral therapy (ART) is highly effective at reducing viral replication, restoring CD4+ T-cells in the blood, and preventing AIDS in human immunodeficiency virus (HIV) infected people. However, ART cannot deplete ... -
Understanding Chronic Lung Infections after Correcting the Basic Cystic Fibrosis Defect
Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In 2012, the first drug that can correct the physiologic defect was approved. These ...