Now showing items 1-5 of 5
Regulation of the flagellar specific sigma factor, sigma28, of Salmonella typhimurium by the anti-sigma factor FlgM
Expression of the flagellar genes of Salmonella typhimurium occurs in an ordered hierarchy that is coupled to the morphogenesis of the flagellar organelle. Transcription of the late (Class 3) flagellar genes is dependent upon a positive transcriptional regulatory protein, the flagellar specific sigma factor, sigma28, encoded ...
The interferon induced serine/threonine protein kinase, PKR, is regulated by the influenza virus activated protein, P58IPK, and the molecular chaperones, Hsp40 and Hsp70
P58IPK is a TPR-containing protein with homology to the J-domain of DnaJ. P58IPK was first recognized for its ability to inhibit the interferon-induced double-stranded RNA-activated serine/threonine protein kinase, PKR, in cells infected with influenza virus. PKR is activated in response to viral infection and downregulates ...
Regulation of protein synthesis and induction of oncogenesis by a cellular protein kinase inhibitor
P58IPK is a cellular inhibitor of the interferon-induced, dsRNA-activated, serine/threonine kinase, PKR. Earlier, P58IPK was shown to block both PKR autophosphorylation and the phosphorylation of eIF-2alpha substrate in vitro, in a dose-dependent manner. Furthermore, murine cell lines overexpressing P58IPK were tumorigenic ...
The mechanisms of Pol expression and assembly for human foamy virus
In this study, I have examined the role of Pol in the replication pathway of HFV. We discovered that unlike all known retroviruses, the Pol protein is expressed independently of Gag from a spliced mRNA, rather than as a Gag-Pol fusion protein. Subsequently, I compared the basic assembly strategies of foamy viruses, retroviruses ...
Taxonomy, biogeography, and evolution of polar gas vacuolate bacteria
Over 250 gas vesicle producing (gas vacuolate) bacteria have been isolated from arctic and antarctic sea ice and water (Irgens et al., 1989; Staley et al., 1989; Gosink et al., 1993; Gosink and Staley, 1995). These strains are the first reported examples of heterotrophic gas vacuolate bacteria from a marine environment and ...