Now showing items 1-4 of 4
Host responses to Salmonella typhimurium infection in vitro and in vivo
Salmonella spp. are facultative intracellular pathogens capable of causing localized and systemic disease of significant morbidity and mortality; disease can be prevented by oral immunization with viable attenuated bacteria. During the Salmonella-host interaction, multiple processes occur that determine the outcome of infection. ...
Identification of factors involved in processing of mRNA in a fimbrial operon of Escherichia coli
Endonucleolytic cleavage of mRNA in the daa operon of Escherichia coli is responsible for coordinate regulation of genes involved in F1845 fimbrial biogenesis. Cleavage occurs by an unidentified endoribonuclease and involves translation of daaP which spans the processing site. It was previously determined that the amino acid ...
Population genetics of human immunodeficiency virus type 1 during within-host chronic infection
Human immunodeficiency virus type 1 (HIV-1) has high replication and mutation rates that generate large census populations and high levels of genetic variation. Furthermore, there is now widespread global circulation of HIV-1 strains that are recognized to be recombinants of preexisting strains. To elucidate the roles natural ...
Formaldehyde metabolism in Methylobacterium extorquens AM1
Methylotrophic bacteria are capable of growth on single-carbon compounds as their sole source of carbon and energy. This metabolism entails the production of formaldehyde as a central intermediate. Methylobacterium extorquens AM1 possess two pterin-linked C1 transfer pathways that are critical for methylotrophic growth. These ...