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Posttranslational regulation and effector specificity of the type VI secretion system
Bacteria mediate interactions with their surroundings by exporting a variety of proteins into the extracellular environment. Gram-negative bacteria have evolved at least six dedicated secretory pathways to accomplish this task, each exporting a discrete set of proteins through complex and genetically divergent systems. One ...
Function, localization and regulation of the Pseudomonas aeruginosa diguanylate cyclase response regulator WspR
WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of <italic>Pseudomonas aeruginosa</italic> on surfaces. Active WspR produces c-di-GMP, which in turn stimulates biofilm formation. Previous work demonstrated that when phosphorylated in ...