Now showing items 1-6 of 6
Posttranslational regulation and effector specificity of the type VI secretion system
Bacteria mediate interactions with their surroundings by exporting a variety of proteins into the extracellular environment. Gram-negative bacteria have evolved at least six dedicated secretory pathways to accomplish this task, each exporting a discrete set of proteins through complex and genetically divergent systems. One ...
Mechanisms of inflammasome activation and inhibition during Yersinia infection
The host inflammatory response is strikingly delayed during the initial stages of infection with Yersinia pestis and Y. pseudotuberculosis, pathogens that can suppress immune defenses. This work identifies the bacterial leucine-rich repeat protein YopM as an inhibitor of pyroptosis, an inflammatory programmed cell death ...
The cyclic-di-GMP receptors of S. Typhimurium: testing their signaling specificity through second messenger affinity and their use as biosensors
c-di-GMP is a second messenger that regulates motility and the production of adhesive factors in many bacterial species. Enzymes containing specific c-di-GMP metabolizing domains integrate information about the environment into an intracellular level of c-di-GMP that then binds to specific downstream receptors, including ...
Oral Polymicrobial Communities in Health and Disease
The oral microbial community represents the best-characterized consortium associated with the human host. There are strong correlations between the qualitative composition of the oral microbiota and clinically healthy or diseased states. However, additional studies are needed to elucidate the mechanisms that define these ...
Function, localization and regulation of the Pseudomonas aeruginosa diguanylate cyclase response regulator WspR
WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of <italic>Pseudomonas aeruginosa</italic> on surfaces. Active WspR produces c-di-GMP, which in turn stimulates biofilm formation. Previous work demonstrated that when phosphorylated in ...
Latent Kaposi's Sarcoma Herpesvirus regulates host factors to induce Lymphangiogenesis and Angiogenesis
Kaposi's Sarcoma herpesvirus (KSHV), the etiologic agent of Kaposi's Sarcoma, is present in the predominant tumor cells of KS, the spindle cells. Spindle cells express markers of lymphatic endothelium and, interestingly, KSHV infection of blood endothelial cells reprograms them to a lymphatic endothelial cell phenotype. ...