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Latent Kaposi's Sarcoma Herpesvirus regulates host factors to induce Lymphangiogenesis and Angiogenesis
Kaposi's Sarcoma herpesvirus (KSHV), the etiologic agent of Kaposi's Sarcoma, is present in the predominant tumor cells of KS, the spindle cells. Spindle cells express markers of lymphatic endothelium and, interestingly, KSHV infection of blood endothelial cells reprograms them to a lymphatic endothelial cell phenotype. ...