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Bacterial Innate Immunity: Mechanisms of PhoQ Sensing that Promote Salmonella Virulence
Salmonella PhoQ is a histidine kinase with a periplasmic sensor domain that promotes virulence by detecting the hostile environment of the host macrophage phagosome. PhoQ kinase activity is repressed by divalent cations and induced in environments of acidic pH, limited divalent cations, and cationic antimicrobial peptides ...
Posttranslational regulation and effector specificity of the type VI secretion system
Bacteria mediate interactions with their surroundings by exporting a variety of proteins into the extracellular environment. Gram-negative bacteria have evolved at least six dedicated secretory pathways to accomplish this task, each exporting a discrete set of proteins through complex and genetically divergent systems. One ...
Mechanisms of inflammasome activation and inhibition during Yersinia infection
The host inflammatory response is strikingly delayed during the initial stages of infection with Yersinia pestis and Y. pseudotuberculosis, pathogens that can suppress immune defenses. This work identifies the bacterial leucine-rich repeat protein YopM as an inhibitor of pyroptosis, an inflammatory programmed cell death ...