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Essential Role of Protein Kinase R Antagonism by TRS1 in Human Cytomegalovirus Replication
Human cytomegalovirus (HCMV) lacking TRS1 and IRS1 (HCMV[ΔI/ΔT]) cannot replicate in cell culture. Although both proteins can block the protein kinase R (PKR) pathway, they have been reported to have multiple other activities and binding partners. It remains unknown which of these functions are essential for HCMV replication. ...