Browsing Molecular and cellular biology by Title

Now showing items 7-26 of 102

B cells promote inflammatory T cell responses during the initiation of central nervous system autoimmune disease

Pierson, Emily (2013-07-25)

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) mediated by autoreactive T cells specific for myelin proteins. A recent development in MS treatment is the discovery that ...
BRCA genes: conserved regions and the potential effect of missense changes

Ramirez, Christina J (2005)

Half of coding single-nucleotide polymorphisms in the human genome result in missense changes. Many are rare, weakly penetrant, or occur in genes for which functional assays are not available. Comparative analysis of protein ...
Bypassing androgen pathway dependence in advanced prostate cancer.

Bluemn, Eric Gregory (2012-09-13)

Continued reliance of castration-resistant prostate cancer (CRPC) on androgen receptor (AR) signaling has spurred the development of novel, potent antiandrogen therapeutics. The clinical use of successively more potent ...
C. elegans Germline Defense Against Retrotransposons

Dennis, Shannon Marie (2012-09-13)

Nematodes appear to have efficient defenses against the germline activity of retroviruses and retrotransposons, as evidenced by the small number of sequences in their genome derived from such elements. No viruses that ...
Characterization of Mitochondrial DNA Mutations in Drosophila melanogaster

Itsara, Leslie (2014-04-30)

Mitochondria are vital organelles as they produce the majority of cellular energy in the form of ATP through oxidative phosphorylation (OXPHOS). Mitochondria contain their own genome (mtDNA), which encodes essential ...
Characterization of novel, context-dependent modulators of WNT signaling in cancer

Anastas, Jamie Nicole (2013-07-23)

WNTs comprise a family of secreted proteins that play critical roles in both embryogenesis and in the etiology of human diseases such as cancer. Even after more than three decades of research, our understanding of the ...
Characterization of organelle morphology and DNA repair in replicatively aging yeast

Hsu, Jessica (2013-11-14)

Aging is one of the most ubiquitous processes in biology, and yet, how the aging process is initiated and the mechanisms that govern how an organism ages remain largely unknown. The study of human aging has been impeded ...
Characterization of the Ipl1/Aurora protein kinase in chromosome segregation and the spindle checkpoint

Pinsky, Benjamin Alan (2005)

The flawless execution of cell division is fundamental to the formation and survival of living organisms. It depends on the accurate and orderly partitioning of chromosomes, resulting in two daughter cells with the correct ...
Characterization of the Isw1a and Isw1b ATP-dependent chromatin remodeling complexes from the budding yeast, Saccharomyces cerevisiae

Vary, James Corydon, 1971- (2003)

Members of the ISWI class of ATP-dependent chromatin remodeling complexes have been found in nearly every eukaryote studied, suggesting important functions that have been conserved throughout evolution. The budding yeast, ...
Characterization of the Warburg Effect and Crabtree effect in Barrett's Esophagus Cell lines and Development of a Chip-Based Single-Cell Respirometry System

Suchorolski, Martin Thomas (2012-05-31)

This thesis consisted of two distinct parts: In the first part, Warburg and Crabtree effects on energy metabolism were characterized in cell lines derived from premalignant Barrett's esophagus patients; in the second part, ...
Characterizing the neutralizing antibody responses of HIV-1 superinfected individuals

Cortez, Valerie

Eliciting a neutralizing antibody (Nab) response that is protective against diverse HIV-1 variants presents a major challenge to vaccine development. The identification of broad, cross-reactive Nabs from HIV-infected ...
Chromatin landscape of the "dark matter of the genome": centromeres of S. cerevisiae and repeat sequences of D. melanogaster.

Krassovsky, Kristina

The chromatin landscape plays a major role in defining cell phenotypes through transcriptional regulation and specification of the main features of chromosome, such as centromeres and pericentric heterochromatin. Studies ...
Chromatin Remodeling Around Nucleosome Free Regions Represses Non-Coding RNA By DNA Looping and Transcription Factor Dependent Targeting of Isw2

Yadon, Adam Nicholas (2013-02-25)

The efficient three-dimensional packaging of DNA into eukaryotic nuclei is accomplished through spatially organizing and compacting DNA into chromatin. Maintaining proper access to DNA, by modulation of either the location ...
Comprehensive, precision genomics

Adey, Andrew (2014-04-30)

The past decade has observed a significant drop in the cost-per-base of DNA sequencing. Driven by a new era of `next-generation' sequencing (NGS), there has been an explosion of new technologies that utilize DNA sequencing, ...
Computational Design and Directed Evolution of Novel Enzymes

Smith, Matthew (2013-11-14)

Enzymes are the most specific and active catalysts found in nature, and offer unique chemical properties suited to solving important industrial, medical, and environmental problems. In this work I present new methods for ...
Computational design of protein-protein interactions to engineer novel inhibitors of the p53 pathway and the polycomb repressive complex

Moody, James

Here I present 2 examples of the application of the Rosetta macromolecular modeling software suite to the successful development of novel protein-based inhibitors with the aim of creating useful tools for the greater cancer ...
Data-driven inference of dynamic transcriptional regulatory mechanisms in prokaryotes: a systems perspective

Brooks, Aaron Neil

Microbes tailor their physiology to diverse environments despite having streamlined genomes and few regulators. Mechanisms by which microbes expand their genetic repertoire include modular reorganization of genetic expression ...
Dimerization of the Fbw7 ubiquitin ligase impacts substrate regulation, tumor suppressor activity

Larimore, Elizabeth Anne (2013-02-25)

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Discovering and Characterizing New Homing Endonucleases for Genome Engineering

Jacoby, Kyle Martin (2013-11-14)

LAGLIDADG Homing Endonucleases (LHEs) are a family of highly specific DNA-cutting enzymes capable of recognizing target sequences of ~20 bp. In many eukaryotes, including humans and yeast, double-strand breaks induced by ...
Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle

Judge, Luke Milburn (2006)

Duchenne Muscular Dystrophy (DMD) is a fatal genetic disorder characterized by severe and progressive muscle degeneration, which is caused by mutations in the gene encoding the dystrophin protein. Dystrophin is required ...

Now showing items 7-26 of 102

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