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Browsing Molecular and cellular biology by Title
Now showing items 97-116 of 301
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Engineered plasma cells: a novel platform for long-term delivery of biologics to treat leukemia and other diseases
Advances in genome-engineering have enabled the generation of human plasma cells that secrete therapeutic proteins and are capable of long-term in vivo engraftment in humanized mouse models. To assist the clinical translation ... -
Engineering yeast cytosine deaminase for improved efficacy in cancer gene directed enzyme prodrug therapy
(2007)Conventional treatment of cancer typically involves some combination of surgery coupled with radio- or chemotherapy. Prognosis in cases of tumor metastasis or inoperable solid-tumors remains grim as cancer cells are often ... -
Environmental Stress Can Favor Cooperation by Triggering an Adaptive Race Between Cooperators and Cheaters
(2013-11-14)Resolving the apparent paradox of the almost universal success of cooperation despite its vulnerability to cheating has been the focus of decades of theoretical and experimental research. Cooperators pay a cost to produce ... -
Epigenomic Regulation of Development and Regeneration in the Mammalian Retina
Diseases and damage to the retina lead to broad losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from Müller ... -
Epithelial morphogenesis of the Caenorhabditis elegans pharynx
(2012-05-31)The assembly of cells into functional organs requires the coordination of cell shape and polarity with organ architecture. Although defects in cell shape and polarity can lead to human disease, the in vivo regulation of ... -
Eradication of the latent HIV viral reservoir: Targeted disruption of the integrated HIV provirus using engineered meganucleases and quantitation of the latent HIV reservoir using multiplex ddPCR
The major barrier to HIV cure is the establishment of a long-lived latent viral reservoir that is not affected by combination ant-retroviral therapy and is not cleared by the immune system. When HIV positive patients on ... -
Evaluating Determinants of Mitochondrial Mutagenesis and their Intersections with Cell Fate
Mitochondria are critical components of cellular metabolism as mediators of oxidative phosphorylation. As semi-autonomous organelles, mitochondria possess their own DNA (mtDNA) which encodes elements of the electron transport ... -
Evaluating Properties of Dystrophin and Delivery Methods of rAAV Gene Therapy for Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a recessive muscle wasting disease caused by a deleterious mutation in the gene encoding the dystrophin protein. Dystrophin is an integral component the dystrophin-glycoprotein complex ... -
Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
Despite significant advances in scientific research and the advent of treatment and prevention strategies over the past several decades, the HIV/AIDS pandemic continues to pose a significant threat to public health. Nearly ... -
Evolution and Development of the Stickleback Lateral Line
(2013-11-14)The lateral line sensory system allows fish to sense water movement. It has been implicated in many behaviors, including schooling, prey detection and capture, and rheotaxis. The number and arrangement of neuromasts in the ... -
Evolution of antiviral breadth in Mx GTPases
As obligate parasites, viral pathogens coopt host resources and subvert cellular processes to promote their own replication. In response, host organisms have evolved numerous countermeasures to thwart viral infection. ... -
Evolution of soft-shell clam transmissible cancer
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living past the death of the founder animal in which the cancer initiated. Using genomic and transcriptomic analyses, we investigated the ... -
Evolution of Synthetic Nucleocapsids Encapsulating their own RNA genome
Viruses are the simplest example of a fundamental feature of biology— they maintain genotype phenotype linkage in complex biochemical environments by encapsulating and protecting a nucleic acid genome. This allows evolution ... -
Evolution-guided design of super restrictor antiviral proteins
Host-virus evolutionary arms-races are driven by antagonistic interactions and often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated ... -
Evolutionary Relationships, Design, and Biochemical Characterization of Homing Endonucleases
(2012-05-31)Homing endonucleases, found in all forms of microbial life, facilitate the invasion of host genes often in concert with introns or inteins by generating double stranded breaks in conserved coding sequences. There are five ... -
Examination of the phenotypic impacts of Helicobacter pylori diversification within a single host
Helicobacter pylori, one of the most common bacterial pathogens colonizing humans, is the main agent responsible for stomach ulcers and cancer. Certain strain types are associated with increased risk of disease, however ... -
Experimental Characterization of the <italic>Mycobacterium tuberculosis</italic> Gene Regulatory Network
(2012-09-13)Tuberculosis is a massive public health problem on a global scale and the success of <italic>Mycobacterium tuberculosis</italic> is linked to its ability to persist within humans for long periods without causing overt ... -
An Exploration of Stress, Signaling, and Ubiquitin-like Modifiers
Cells face a barrage of internal and external stresses that could inflict severe damage on the molecules essential for life. To cope with environmental challenges, cells have evolved complex stress responses. Posttranslational ... -
An Exploration of the Genetics and Molecular Mechanisms Underlying Conserved Longevity Interventions
(2012-09-13)Aging is a degenerative process that causes a time-dependent deterioration of virtually every biological system in the majority of species. Age is the primary risk factor for many human diseases, including the top causes ... -
Exploring Mechanisms of Cell Shape Control in Helicobacter pylori
Helicobacter pylori chronically infects over half of the global population and is associated with increased risk for gastric cancer, the third leading cause of cancer deaths worldwide. H. pylori resides in the gastric ...