Browsing Molecular and cellular biology by Subject "ELANE; elastase; IRES; neutropenia"
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Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms Hereditary neutropenia usually results from heterozygous germline mutations of ELANE, encoding neutrophil elastase (NE). How mutations cause disease remains uncertain. Two hypotheses have been proposed. In one, ELANE ...