Browsing Molecular and cellular biology by Subject "Oncology"
Now showing items 1-14 of 14
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Antibody Microarray Interrogation of Tissue and Plasma for the Improved Early Detection of Pancreas Cancer
(2014-02-24)Pancreas cancer, most frequently pancreatic ductal adenocarcinoma (PDA), is the tenth most common cancer but is the fourth leading cause of cancer deaths in the United States, with a fiveyear survival rate of just 6%. This ... -
Bypassing androgen pathway dependence in advanced prostate cancer.
(2012-09-13)Continued reliance of castration-resistant prostate cancer (CRPC) on androgen receptor (AR) signaling has spurred the development of novel, potent antiandrogen therapeutics. The clinical use of successively more potent ... -
Characterization of novel, context-dependent modulators of WNT signaling in cancer
(2013-07-23)WNTs comprise a family of secreted proteins that play critical roles in both embryogenesis and in the etiology of human diseases such as cancer. Even after more than three decades of research, our understanding of the ... -
Decoding the B cell receptor in endemic Burkitt Lymphoma: Insights into pathogenesis and implications for disease detection
The African endemic form of Burkitt Lymphoma (BL) is one of the most common pediatric malignancies in sub-Saharan Africa. BL is particularly prevalent in certain geographic regions, likely due to both environmental and ... -
Elucidating Mechanisms of T cell Exclusion in Melanoma
Advanced melanoma was an almost incurable disease in the early 2010s. Today, about half of patients can achieve durable clinical responses with new targeted therapies, including immune checkpoint blockade therapies. The ... -
Identification and Mechanistic Investigation of Recurrent Functional Genomic and Transcriptional Alterations in Advanced Prostate Cancer
(2014-02-24)Novel functionally altered transcripts may be recurrent in prostate cancer (PCa) and may underlie lethal and advanced disease and the neuroendocrine small cell carcinoma (SCC) phenotype. We conducted an RNASeq survey of ... -
Identification of Cancer-Specific Essential Genes in Glioblastoma Multiforme
(2013-04-17)Glioblastoma multiforme (GBM) is the most common and aggressive type of brain cancer and is notoriously drug and radiation resistant. Current therapies and trials have repeatedly failed to substantially increase the survival ... -
Identification of Cancer-specific Therapeutic Targets and Tumor Suppressor Genes in Glioblastoma Multiforme by Functional Genetics
Glioblastoma Multiforme (GBM) is the most common and aggressive form of brain cancer. ~90% of adult GBM patients receiving standard of care therapies die within 2 years of diagnosis due to ineffective therapies. To ... -
Investigating Drivers of Chemoresistance in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by rapid emergence of chemoresistant disease. To study the role of MYC family members in SCLC ... -
Patient 3’UTR mutations regulate post-transcriptional gene expression and cellular oncogenicity in prostate cancer
While cancer genomics has historically focused on the coding genome, the 3' untranslated region (3’UTR) represents a largely unexplored avenue for uncovering alternative genetic drivers of disease. The 3’UTR controls mRNA ... -
Predicting cancer subtypes from nucleosome profiling of cell-free DNA
Modern cancer treatments take advantage of genomic differences between tumors to kill cancer cells using targeted approaches. Typically, this requires a tumor biopsy in order to get tissue for phenotypic and genotypic ... -
Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
Fbw7 is the substrate binding subunit of an SCF E3 ubiquitin ligase, which catalyzes the polyubiquitylation of substrates, initiating their recognition and degradation by the proteasome. The affinity of Fbw7 for its ... -
Signaling Analyses of Therapeutic T cells Engineered with Synthetic Receptors
Revolutionary new cancer therapies are harnessing the power of our immune systems. One type of cancer immunotherapy employs T cells that are genetically re-programmed to efficiently recognize and attack a patient’s tumor. ... -
Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
(2012-08-10)Medulloblastoma is a developmental cancer of the cerebellum. It continues to be the most common pediatric brain cancer associated with dire survival and impaired quality of life. In order to develop therapeutic interventions, ...