Browsing Molecular and cellular biology by Author "Nelson, Peter S"
Now showing items 1-4 of 4
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Bypassing androgen pathway dependence in advanced prostate cancer.
Bluemn, Eric Gregory (2012-09-13)Continued reliance of castration-resistant prostate cancer (CRPC) on androgen receptor (AR) signaling has spurred the development of novel, potent antiandrogen therapeutics. The clinical use of successively more potent ... -
Identification and Mechanistic Investigation of Recurrent Functional Genomic and Transcriptional Alterations in Advanced Prostate Cancer
White, Thomas Alonzo (2014-02-24)Novel functionally altered transcripts may be recurrent in prostate cancer (PCa) and may underlie lethal and advanced disease and the neuroendocrine small cell carcinoma (SCC) phenotype. We conducted an RNASeq survey of ... -
Identifying mechanisms of initiation and maintenance of neuroendocrine prostate cancer
Corella, Alexandra NicoleSmall cell or neuroendocrine prostate cancer (SCNPC) is a rare but aggressive subtype of prostate cancer with no FDA-approved targeted therapies. SCNPC is an androgen-receptor independent subtype that often emerges as ... -
Interaction of the miR-106a~363 microRNA cluster and the p27Kip1 CDK inhibitor in T cell development and lymphomagenesis
Kuppers, Daniel (2012-05-31)MicroRNAs are 21-22 nucleotide RNAs that regulate gene expression by binding mRNA 3' UTRs and inhibiting translation or targeting them for degradation. The Xpcl1 locus, encoding the miR-106a~363 miRNA cluster, was first ...