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Implications of myelin basic protein processing and presentation on T cell activation and tolerance
Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis which can be induced by immunization with myelin antigens such as myelin basic protein (MBP). Immune tolerance influences the repertoire of MBP-specific T cells in B10.PL mice. MBPAc1--11-specific T cells escape tolerance while ...