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Hepatocyte determinants of susceptibility to pre-erythrocytic Plasmodium infection
Malaria is caused by eukaryotic parasites of the genus Plasmodium. They have coevolved with their mammalian hosts, significantly shaping both parasite and host genomes. It is the most deadly parasitic infection in the world, with approximately 200 million clinical episodes annually and nearly half a million deaths, mostly ...
Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
(2013-07-25)
Chronic Hepatitis C affects an estimated 170 million people worldwide and 4 million in the United States. The pro-inflammatory chemokine CXCL10 is induced by hepatitis C virus (HCV) infection <italic>in vitro</italic> and <italic>in vivo</italic>, and is associated with the outcome of interferon (IFN)-based therapies. Since ...
Targeting tumor tight junctions: The Junction Opener protein
With the advent of new approaches - including cellular therapy and immunotherapies - cancer treatment has entered a new era. However, solid epithelial tumors have yet to benefit from these new modalities, and new tools for diagnosis and treatment are sorely needed. Desmoglein-2 (DSG2) is a desmosomal protein involved in ...
Chlamydia trachomatis overcomes human cell-autonomous immunity through secretion of a novel inclusion membrane protein IncU
Chlamydia is the most common sexually transmitted bacterial infection in the world. In the United States, over 100 million people are infected each year, and from 2015 to 2019 incidence of chlamydia rose by 19%. Of extreme concern, this increase has occurred despite readily available effective antibiotics and national screening ...
Impact of HIV Drug Resistance on Maternal Treatment Outcome & Vertical Transmission
HIV pretreatment drug resistance – defined as resistance detected prior to the initiation of antiretroviral therapy (ART) – has increased in prevalence over time in parallel with the increased global utilization of ART. The prevalence of pretreatment drug resistance has surpassed 10% to non-nucleoside reverse transcriptase ...