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Mechanism of physiological function of sphingosine-1-phosphate: extracellular action and demonstration of alleged receptor
(1998)
Sphingosine-1-phosphate (Sph-1-P), the first product of sphingosine (Sph) catabolism, causes changes of cell physiology when exogenously added to culture medium. Cellular response varies depending on type of cell. For example: (i) 10-20 $\mu$M exogenous Sph-1-P causes shape change and aggregation of platelets. (ii) 10-100 nM ...
The isolation and characterization of inflammatory polypeptides from Staphylococcus epidermidis
(1998)
Septic shock is the result of an overwhelming immune response to bacterial products, or modulins. Lipopolysaccharide is the primary modulin involved in Gram negative sepsis, but an analogous agent from Gram positive bacteria has not yet been identified. In order to characterize what such a modulin might be, a hospital strain ...
Animal models of Chlamydia pneumoniae and atherosclerosis: dissemination to and persistence in atheromatous lesions
(1996)
Chlamydia pneumoniae has been associated with atherosclerosis in humans. The goal of this dissertation is to evaluate animal models of both C. pneumoniae and atherosclerosis to investigate the pathogenesis of C. pneumoniae in atherosclerosis. New Zealand White (NZW) and Watanabe heritable hyperlipidemic (WHHL) rabbits and ...
Prevalence and mechanisms of antibiotic resistance in oral bacteria
(1996)
Periodontitis occurs in 15% of adults with teeth. Antibiotics are used as an adjunct to standard mechanical therapy for the treatment of periodontitis. As antibiotic use has increased, many bacteria have acquired resistance mechanisms. In the work presented here, the prevalence of antibiotic resistance was determined for ...
Genetic diversity, evolution, and fitness of infectious hematopoietic necrosis virus within an endemic focus in rainbow trout aquaculture
(2002)
The rhabdovirus infectious hematopoietic necrosis virus (IHNV) is the most significant viral pathogen of salmon and trout in North America. The virus infects wild, hatchery, and farmed fish populations from Alaska to California and inland to Idaho, causing disease with up to 90% mortality. In the 41 mile Hagerman Valley of ...