Pathology
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A genome-scale gain-of-function screening platform nominates genetic modulators for CAR T cell therapy enhancement
Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer care through genetic reprogramming, and next-generation cell engineering aims to encode increasingly complex genetic programs to further modulate T ... -
Impact of proteasomal processing on immunopeptidome repertoires and therapeutic immune recognition.
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. AML often responds to initial chemotherapy, but a majority of patients will relapse with resistant disease leaving a critical need for more effective ... -
An Automated System For High-Throughput Longevity and Healthspan Discovery in Caenorhabditis elegans
Over the last century, the study of aging biology has primarily been advanced through the development and use of animal models that share common molecular hallmarks with human aging. One major model system that has been ... -
Utility of kidney organoids for disease modeling and therapeutic development
Chronic kidney disease (CKD) affects 1 in 7 adults and is the 10th leading cause of death in the United States in 2022. Kidney transplant and dialysis remain the leading treatment strategies for kidney failure despite their ... -
Molecular and Spatial Regulators of Cardiac Fibroblast Cell State and Plasticity in Myocardial Infarction Injury
A central obstacle in heart disease is the replacement of healthy kinetic muscle with stiff fibrotic scarring. Fibrotic deposition represents a major clinical burden because it rapidly progresses the heart towards failure ... -
Enhancing Local delivery of Macrophage Checkpoint Inhibitors with Chemokine Gradients to Lure and Destroy Pediatric Brain Tumor Cells
Pediatric brain tumors (PBTs) are the leading cause of cancer-related death in children. These malignancies tend to occur in locations of the brain where complete resection and adjuvant therapy could lead to an impaired ... -
Genomic Instability at Single Cell Resolution
All organisms maintain the integrity of their genome through highly precise DNA replication and repair. Errors in these mechanisms can lead to genetic instability that results in cellular dysfunction or malignancy. Modern ... -
The regulation and function of C. elgans flavin-containing monooxygenase-2
In the last one hundred years, aging has become an increasingly tractable problem. The pioneering dietary restriction experiments of the 1920s and '30s, the robust evolutionary and molecular theories of the 1950s -'70s, ... -
The Microbial Etiology of Colorectal Cancer
The microbiome of the Gastro-Intestinal tract is estimated at 100 trillion organisms which act in a symbiotic relationship with the surrounding tissue cells to maintain homeostasis. However, alterations in the gut microbiota ... -
Natural genetic and phenotypic variation for aging
Aging is a complex, highly variable trait influenced by genes, environment, and the interaction between the two. While aging is universal across nearly all species in the animal kingdom, there are many different ways an ... -
Characterizing the role of DDX3X in DNA double strand break repair; Implications for lymphocyte biology
DDX3X is a human, ATP-dependent RNA helicase with roles throughout RNA metabolism. A number of human diseases are associated with alterations in this gene, particularly in hematological malignancies. We aimed to investigate ... -
Identification of hypothalamic neural circuits regulating glucose and energy homeostasis
Diabetes and obesity are among the most common and costly health issues facing modern humans. The World Health Organization (WHO) estimates that obesity rates have tripled in the last 50 years: as of 2016, nearly 40% of ... -
Identifying and Characterizing Novel Targets against Rhabdomyosarcoma Disease Relapse
Rhabdomyosarcoma (RMS) is the most common soft tissue pediatric sarcoma. Patients with relapsed or metastatic disease are faced with a poor survival outlook. Self-renewal of tumor propagating cells (TPCs) is believed to ... -
Mechanism of Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1
The rising prevalence of type 2 diabetes mellitus (T2D) is a major health concern worldwide. Growing evidence of a role for the brain in glucose homeostasis has stimulated interest in therapeutic approaches that target the ... -
Molecular and Cellular Mechanisms of Mycobacterial Glycolipid Recognition by Human T Cells
Tuberculosis (TB) is of high global health importance and disproportionately affects individuals in resource-limited settings. A major challenge to reducing the global burden of this disease is the lack of effective ... -
Deciphering the relationship among nutrition, host and microbe
Within the human gastrointestinal tract, there are trillions of resident microbes collectively known as the gut microbiota. These organisms have a profound impact on host physiology, particularly the immune system. Upon ... -
Modeling autoimmune associated genetics in primary human T cells using CRISPR/Cas9 gene editing
Genome wide association studies have identified genetic risk variants associated with multiple autoimmune diseases, thereby impacting large numbers of patients. Prominent examples are found within the phosphatase encoding ... -
miR-155 expression modulates microglia functions in vitro and in the APP/PS1 mouse model of Alzheimer’s disease
Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular Amyloid-β (Aβ) as well as both CNS and systemic inflammation. Microglia, myeloid cells resident to the CNS, use microRNAs to rapidly respond ... -
Molecular genetics of myeloid malignancy predisposition: Insights into pathogenesis and therapeutic translation
Preleukemic diseases are highly informed by genetic predisposition and require appropriate models for studying pathogenesis and the progression to hematological malignancy. Although rare, familial platelet disorder (FPD) ... -
The Role of Early Autocrine IL-2 Signals in Programming Antigen-Specific CD8 T cell Responses
IL-2 is a potent cytokine in mediating antigen-specific CD8 T cell responses. Following antigen priming, IL-2 signals drive the differentiation of resting cytotoxic T cells into potent effector cells to elicit rapid ...
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