Browsing Pathology by Title
Now showing items 26-45 of 60
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Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype
(2013-07-23)<italic>Rationale:</italic> Phagocytosis of apoptotic cells (efferocytosis) is mediated by apoptotic cell receptors and is essential for resolution of inflammation. In chronic inflammation, apoptotic cell clearance is ... -
Mechanism of Diabetes Remission Induced by the Central Action of Fibroblast Growth Factor 1
The rising prevalence of type 2 diabetes mellitus (T2D) is a major health concern worldwide. Growing evidence of a role for the brain in glucose homeostasis has stimulated interest in therapeutic approaches that target the ... -
Mechanism of endocytosis of CD33/Siglec-3: role of ITIMs, tyrosine phosphorylation, and monoubiquitylation
(2006)The sialic acid-binding immunoglobulin-like lectin, CD33/Siglec-3, is a founding member of a subgroup of highly related Siglecs with differential expression in the innate immune system. Common structural features include ... -
Mechanisms of shear stress-mediated ERK1/2 modulating signal transduction pathways in endothelial cells
(1998)Mechanical forces are important modulators of cellular function in various tissues and are particularly important in the cardiovascular system. The endothelial cell layer, by virtue of its unique location in the vessel ... -
Merkel Cell Carcinoma: Immunogenicity and the characterization of CD4 T cell responses to the Merkel cell polyomavirus
Merkel cell carcinoma (MCC) is a deadly, virus-associated skin cancer with a 5-year relative mortality rate of 46%. The Merkel cell polyomavirus (MCPyV) is clonally integrated into 80% of MCCs and persistent expression of ... -
Merkel cell polyomavirus-specific CD8 T cells in Merkel cell carcinoma: T cell receptor diversity & novel immune therapies
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a disease-specific mortality of 46%. Unfortunately, no FDA-approved treatments for advanced disease exist. Over 80% of MCCs are caused by persistent expression ... -
Merkel cell polyomavirus-specific T cell responses, immune evasion mechanisms & immune therapy in Merkel cell carcinoma
(2013-07-25)Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with an increasing incidence and a 5-year disease-associated mortality of 46%. The Merkel cell polyomavirus (MCPyV), discovered in 2008, is involved ... -
miR-155 expression modulates microglia functions in vitro and in the APP/PS1 mouse model of Alzheimer’s disease
Alzheimer’s Disease (AD) is characterized by the accumulation of extracellular Amyloid-β (Aβ) as well as both CNS and systemic inflammation. Microglia, myeloid cells resident to the CNS, use microRNAs to rapidly respond ... -
Mitochondrial Dynamics in the Presence of Neurodegenerative Disease
(2014-04-30)Mitochondrial dysfunction is an early event in many neurodegenerative diseases, with impaired bioenergetics and migration acting as neurodegenerative triggers. Mitochondrial disruption in the form of reduced bioenergetic ... -
Modeling autoimmune associated genetics in primary human T cells using CRISPR/Cas9 gene editing
Genome wide association studies have identified genetic risk variants associated with multiple autoimmune diseases, thereby impacting large numbers of patients. Prominent examples are found within the phosphatase encoding ... -
Molecular and Cellular Mechanisms of Mycobacterial Glycolipid Recognition by Human T Cells
Tuberculosis (TB) is of high global health importance and disproportionately affects individuals in resource-limited settings. A major challenge to reducing the global burden of this disease is the lack of effective ... -
Molecular and Cellular Phenotypes of AUTS2 Deficiency in the Developing Mouse Cortex and Hippocampus
Variants in the gene Autism Susceptibility Candidate 2 (AUTS2) are a rare cause of intellectual disability, developmental delay and autistic features in patients. However, the mechanism by which loss of AUTS2 causes specific ... -
Molecular and Spatial Regulators of Cardiac Fibroblast Cell State and Plasticity in Myocardial Infarction Injury
A central obstacle in heart disease is the replacement of healthy kinetic muscle with stiff fibrotic scarring. Fibrotic deposition represents a major clinical burden because it rapidly progresses the heart towards failure ... -
Molecular genetics of myeloid malignancy predisposition: Insights into pathogenesis and therapeutic translation
Preleukemic diseases are highly informed by genetic predisposition and require appropriate models for studying pathogenesis and the progression to hematological malignancy. Although rare, familial platelet disorder (FPD) ... -
Mus dunni endogenous virus (MDEV)
(1998)Retroviral vectors are being increasingly used to deliver genes to human cells which are then returned to a patient' s body, both for medical research and direct therapeutic goals. One requirement in such ex vivo gene ... -
Natural genetic and phenotypic variation for aging
Aging is a complex, highly variable trait influenced by genes, environment, and the interaction between the two. While aging is universal across nearly all species in the animal kingdom, there are many different ways an ... -
Novel Disease Genes Underlying Rare Recessively Inherited Forms Of Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a rare inherited connective tissue disorder affecting bone. Defining features are fragile bones that are highly susceptible to fracture (“brittle bone”) and bone deformation. There is a high ... -
Novel mutations of COL3A1 resulting in Ehlers-Danlos syndrome type IV and their effect on the folding of type III procollagen
(1998)Ehlers-Danlos syndrome type IV (EDS IV) is an inherited disease caused by mutation of COL3A1, the gene that encodes type III procollagen. Different mutations produce the disease: point mutations, exon skipping mutations ... -
Osteopontin structure and function
(1998)Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling. There are several structural domains in osteopontin of particular interest. The RGD motif is a cell-attachment ... -
Pharmaceutical interventions in a murine cardiac aging model
University of Washington Abstract Pharmaceutical interventions in a murine cardiac aging model Autumn L. Tocchi Chair of Supervisory Committee: Peter S. Rabinovitch MD, PhD Professor of Pathology Heart disease is the number ...