Browsing Pathology by Title
Now showing items 44-60 of 60
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Osteopontin structure and function
(1998)Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling. There are several structural domains in osteopontin of particular interest. The RGD motif is a cell-attachment ... -
Pharmaceutical interventions in a murine cardiac aging model
University of Washington Abstract Pharmaceutical interventions in a murine cardiac aging model Autumn L. Tocchi Chair of Supervisory Committee: Peter S. Rabinovitch MD, PhD Professor of Pathology Heart disease is the number ... -
Platelet-derived growth factor receptor alpha signaling pathways in development and liver disease
(2014-04-30)Platelet derived growth factor receptor alpha (PDGFRα) signaling is critical for development and disease. Insufficient PDGFRα signal transduction results in developmental anomalies, while excessive signaling results in ... -
Proteome Turnover in Mouse Aging: In Vivo Studies by Stable Isotope Mass Spectrometry
Introduction: Maintenance of proper protein homeostasis (proteostasis) is essential to cellular and organismal health. A wealth of research has shown that age-related diseases and conditions are associated with the inability ... -
Random mutations, protein mutability, and DNA repair: understanding protein tolerance to random amino acid changes through directed evolution
(2004)In nature, evolution has given rise to the astonishing and wonderful diversity of organisms on this planet. In the laboratory, directed evolution can be a powerful technique to generate variants of a given protein with ... -
Regeneration of retinal neurons from Müller glia in adult mice
There are many diseases that result in the death of specific neuron populations in the retina, resulting in blindness. Currently, few options exist for the treatment of blinding diseases, and the options that are available ... -
Regulator of G-protein signaling 5 is expressed in hepatic stellate cells and moderates the fibrotic response to injury
Liver fibrosis is mediated by hepatic stellate cells (HSCs), which respond to a variety of cytokine and growth factors to moderate the response to injury and create extracellular matrix at the site of injury. G-protein ... -
The Role of Dynamin Like Protein 1 in Parkinson's Disease
(2014-02-24)Parkinson's disease (PD) is a neurodegenerative disease diagnosed by the presence of various motor symptoms, which result from loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In addition to these ... -
Short-term rapamycin persistently improves cardiac function after cessation of treatment in aged male and female mice.
Cardiac aging is an intrinsic process that results in impaired cardiac function and dysregulation of cellular and molecular quality control mechanisms. These effects are evident in the decline of diastolic function, increase ... -
Sleep Apnea Impairs Hippocampal Function and Adult Neurogenesis
Sleep apnea is a respiratory disorder characterized by periods of sleep during which no effective breaths are taken. Recurrent episodes of apnea caused by upper airway obstruction and/or cessation of central respiratory ... -
The consequences of mutator-driven mutagenesis and analysis of lifespan extending compounds using outgrowth analysis and replicative lifespan in Saccharomyces cerevisiae
The hope of dramatically extending our lifespan has captivated humanity for millennia. Over the last two decades, the biology of aging has matured as a field of study and led to greater engagement and investment in aging ... -
The Endocytic Protein FCHO-1 is Essential in Preserving the Structural and Functional Integrity of Neurons
Neurons are vital for animal physiology and behavior, demanding lifelong structural and functional integrity. This integrity is upheld by intricate endocytic pathways that sustain a multitude of critical neuronal features, ... -
The Microbial Etiology of Colorectal Cancer
The microbiome of the Gastro-Intestinal tract is estimated at 100 trillion organisms which act in a symbiotic relationship with the surrounding tissue cells to maintain homeostasis. However, alterations in the gut microbiota ... -
The regulation and function of C. elgans flavin-containing monooxygenase-2
In the last one hundred years, aging has become an increasingly tractable problem. The pioneering dietary restriction experiments of the 1920s and '30s, the robust evolutionary and molecular theories of the 1950s -'70s, ... -
The Role of Early Autocrine IL-2 Signals in Programming Antigen-Specific CD8 T cell Responses
IL-2 is a potent cytokine in mediating antigen-specific CD8 T cell responses. Following antigen priming, IL-2 signals drive the differentiation of resting cytotoxic T cells into potent effector cells to elicit rapid ... -
Transcriptional, metabolic and epigenetic changes associated with in utero diesel exhaust particulate exposure
In utero exposure to diesel exhaust air pollution has been associated with increased adult susceptibility to heart failure in mice but the mechanisms by which this exposure promotes susceptibility are poorly understood. ... -
Utility of kidney organoids for disease modeling and therapeutic development
Chronic kidney disease (CKD) affects 1 in 7 adults and is the 10th leading cause of death in the United States in 2022. Kidney transplant and dialysis remain the leading treatment strategies for kidney failure despite their ...