Browsing Pathology by Subject "Merkel cell polyomavirus"
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Merkel Cell Carcinoma: Immunogenicity and the characterization of CD4 T cell responses to the Merkel cell polyomavirus
Merkel cell carcinoma (MCC) is a deadly, virus-associated skin cancer with a 5-year relative mortality rate of 46%. The Merkel cell polyomavirus (MCPyV) is clonally integrated into 80% of MCCs and persistent expression of ... -
Merkel cell polyomavirus-specific CD8 T cells in Merkel cell carcinoma: T cell receptor diversity & novel immune therapies
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a disease-specific mortality of 46%. Unfortunately, no FDA-approved treatments for advanced disease exist. Over 80% of MCCs are caused by persistent expression ...