Browsing Pathology by Subject "Theses--Pathology"
Now showing items 1-9 of 9
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Development and characterization of a new assay to examine telomere-protein interactions in vivo
(1997)An in vivo telomere binding assay using one-hybrid methodology was devised. A reporter gene, lacZ, was integrated immediately adjacent to a chromosomal telomere in Saccharomyces cerevisiae. If a telomere binding protein ... -
Fas/FADD-induced pro-inflammatory response in vascular smooth muscle cells
(2002)Apoptosis of smooth muscle cells is a common feature of vascular lesions. Unlike necrosis, apoptosis is classically considered to be "silent," i.e., self-contained and non-inflammatory. I have found that signals initiated ... -
The functions of FE65 proteins and their roles in dementias of the Alzheimer type
(2003)Dementias of the Alzheimer type (DAT) are human neurodegenerative diseases that debilitate millions of elderly people, presenting enormous financial and emotional burdens worldwide. Its pathogenesis involves the beta-amyloid ... -
Mechanism of endocytosis of CD33/Siglec-3: role of ITIMs, tyrosine phosphorylation, and monoubiquitylation
(2006)The sialic acid-binding immunoglobulin-like lectin, CD33/Siglec-3, is a founding member of a subgroup of highly related Siglecs with differential expression in the innate immune system. Common structural features include ... -
Mechanisms of shear stress-mediated ERK1/2 modulating signal transduction pathways in endothelial cells
(1998)Mechanical forces are important modulators of cellular function in various tissues and are particularly important in the cardiovascular system. The endothelial cell layer, by virtue of its unique location in the vessel ... -
Mus dunni endogenous virus (MDEV)
(1998)Retroviral vectors are being increasingly used to deliver genes to human cells which are then returned to a patient' s body, both for medical research and direct therapeutic goals. One requirement in such ex vivo gene ... -
Novel mutations of COL3A1 resulting in Ehlers-Danlos syndrome type IV and their effect on the folding of type III procollagen
(1998)Ehlers-Danlos syndrome type IV (EDS IV) is an inherited disease caused by mutation of COL3A1, the gene that encodes type III procollagen. Different mutations produce the disease: point mutations, exon skipping mutations ... -
Osteopontin structure and function
(1998)Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling. There are several structural domains in osteopontin of particular interest. The RGD motif is a cell-attachment ... -
Random mutations, protein mutability, and DNA repair: understanding protein tolerance to random amino acid changes through directed evolution
(2004)In nature, evolution has given rise to the astonishing and wonderful diversity of organisms on this planet. In the laboratory, directed evolution can be a powerful technique to generate variants of a given protein with ...