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Development and characterization of a new assay to examine telomere-protein interactions in vivo
An in vivo telomere binding assay using one-hybrid methodology was devised. A reporter gene, lacZ, was integrated immediately adjacent to a chromosomal telomere in Saccharomyces cerevisiae. If a telomere binding protein fused to a transcriptional activation domain were expressed in such a strain, the telomere binding portion ...