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Mechanism of endocytosis of CD33/Siglec-3: role of ITIMs, tyrosine phosphorylation, and monoubiquitylation
The sialic acid-binding immunoglobulin-like lectin, CD33/Siglec-3, is a founding member of a subgroup of highly related Siglecs with differential expression in the innate immune system. Common structural features include a conserved proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) and a distal ITIM-like motif, ...
Random mutations, protein mutability, and DNA repair: understanding protein tolerance to random amino acid changes through directed evolution
In nature, evolution has given rise to the astonishing and wonderful diversity of organisms on this planet. In the laboratory, directed evolution can be a powerful technique to generate variants of a given protein with novel characteristics. The end products of the selection for desired traits from large combinatorial sets ...
Fas/FADD-induced pro-inflammatory response in vascular smooth muscle cells
Apoptosis of smooth muscle cells is a common feature of vascular lesions. Unlike necrosis, apoptosis is classically considered to be "silent," i.e., self-contained and non-inflammatory. I have found that signals initiated by Fas-associated death domain protein (FADD) overexpression in rat vascular smooth muscle cells in the ...
The functions of FE65 proteins and their roles in dementias of the Alzheimer type
Dementias of the Alzheimer type (DAT) are human neurodegenerative diseases that debilitate millions of elderly people, presenting enormous financial and emotional burdens worldwide. Its pathogenesis involves the beta-amyloid precursor protein (betaPP), the aberrant processing or functioning of which results in amyloid plaques, ...