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Innate Immune Detection of Flagellin Positively and Negatively Regulates Salmonella Infection
(2014-02-24)
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of gastroenteritis in humans. Bacterial flagellin is required for motility and also a prime target of the innate immune system. Innate immune recognition of flagellin is mediated by at least two independent pathways, TLR5 and ...
Merkel cell polyomavirus-specific T cell responses, immune evasion mechanisms & immune therapy in Merkel cell carcinoma
(2013-07-25)
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with an increasing incidence and a 5-year disease-associated mortality of 46%. The Merkel cell polyomavirus (MCPyV), discovered in 2008, is involved in the pathogenesis of over 80% of MCC tumors. MCC typically requires persistent expression of immunogenic ...