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Innate Immune Recognition of Conserved Structural Features of Bacterial Flagellin Shapes Host Antibody Responses
Within this dissertation, we have determined how components of the host's innate immune system and structural features of flagellin, a pathogen associated molecular pattern (PAMP) and the major structural component of bacterial flagella, determine isotype specific antibody responses. Bacteria use flagella for chemotaxis toward ...
Innate Immune Detection of Flagellin Positively and Negatively Regulates Salmonella Infection
Salmonella enterica serovar Typhimurium is a flagellated bacterium and one of the leading causes of gastroenteritis in humans. Bacterial flagellin is required for motility and also a prime target of the innate immune system. Innate immune recognition of flagellin is mediated by at least two independent pathways, TLR5 and ...