Now showing items 1-3 of 3
Human Embryonic Stem Cell-Derived Cardiomyocytes Migrate in Response to Gradients of Fibronectin and Wnt5a: Implications for cardiac repair & congenital heart defects
An improved understanding of the factors that regulate the migration of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) would provide new insights into human heart development and suggest novel strategies to improve their electromechanical integration following intra-cardiac transplantation. Until now, nothing ...
Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype
<italic>Rationale:</italic> Phagocytosis of apoptotic cells (efferocytosis) is mediated by apoptotic cell receptors and is essential for resolution of inflammation. In chronic inflammation, apoptotic cell clearance is dysfunctional and soluble levels of several apoptotic cell receptors are elevated. Reports have identified ...
Merkel cell polyomavirus-specific T cell responses, immune evasion mechanisms & immune therapy in Merkel cell carcinoma
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with an increasing incidence and a 5-year disease-associated mortality of 46%. The Merkel cell polyomavirus (MCPyV), discovered in 2008, is involved in the pathogenesis of over 80% of MCC tumors. MCC typically requires persistent expression of immunogenic ...