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The Role of Dynamin Like Protein 1 in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disease diagnosed by the presence of various motor symptoms, which result from loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In addition to these motor defects, numerous non-motor symptoms occur and appear prior to the onset of clinical symptoms. ...
Platelet-derived growth factor receptor alpha signaling pathways in development and liver disease
Platelet derived growth factor receptor alpha (PDGFRα) signaling is critical for development and disease. Insufficient PDGFRα signal transduction results in developmental anomalies, while excessive signaling results in fibrosis and carcinogenesis. PDGFRα signal transduction is regulated at multiple levels, two of which are ...
Mitochondrial Dynamics in the Presence of Neurodegenerative Disease
Mitochondrial dysfunction is an early event in many neurodegenerative diseases, with impaired bioenergetics and migration acting as neurodegenerative triggers. Mitochondrial disruption in the form of reduced bioenergetic capacity, increased oxidative stress and reduced resistance to stress is observed in several disease models. ...