Merkel cell carcinoma (MCC) is an aggressive skin cancer with a disease-specific mortality of 46%. Unfortunately, no FDA-approved treatments for advanced disease exist. Over 80% of MCCs are caused by persistent expression of T-antigen oncoproteins from the Merkel cell polyomavirus (MCPyV). Systemic immunity is strongly linked ...

Merkel cell carcinoma (MCC) is a deadly, virus-associated skin cancer with a 5-year relative mortality rate of 46%. The Merkel cell polyomavirus (MCPyV) is clonally integrated into 80% of MCCs and persistent expression of MCPyV T-antigen oncoproteins is required for tumor survival and growth, potentially providing ideal targets ...