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Merkel cell polyomavirus-specific CD8 T cells in Merkel cell carcinoma: T cell receptor diversity & novel immune therapies
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a disease-specific mortality of 46%. Unfortunately, no FDA-approved treatments for advanced disease exist. Over 80% of MCCs are caused by persistent expression of T-antigen oncoproteins from the Merkel cell polyomavirus (MCPyV). Systemic immunity is strongly linked ...
Merkel cell polyomavirus-specific T cell responses, immune evasion mechanisms & immune therapy in Merkel cell carcinoma
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with an increasing incidence and a 5-year disease-associated mortality of 46%. The Merkel cell polyomavirus (MCPyV), discovered in 2008, is involved in the pathogenesis of over 80% of MCC tumors. MCC typically requires persistent expression of immunogenic ...