Browsing Pharmaceutics by Title
Now showing items 36-55 of 80
-
Function and Regulation of Cytochrome P450 4V2 and the Implications in Bietti’s Crystalline Dystrophy
Background: Cytochrome P450 4V2 (CYP4V2) is one of 57 functional human isozymes in the cytochrome P450 superfamily of heme-containing monooxygenase enzymes. CYP4V2 is one of thirteen human P450 enzymes classified as ‘orphans’ ... -
The impact of adherence and an intervention program on patient outcomes and costs in chronic hepatitis C infection
(2012-09-13)<bold>Background and aims:</bold> Both observational studies and randomized trials have shown that higher medication adherence is associated with improved outcomes in patients with chronic hepatitis C infection (CHC). ... -
The Impact of CYP3A5 Variation and Pregnancy on the Metabolic Disposition of Calcineurin Inhibitors
(2013-02-25)The calcineurin inhibitors (CNI) — cyclosporine A (CsA) and tacrolimus remain the backbone of immunosuppression therapy for most organ transplant patients despite their serious side effects, such as chronic calcineurin ... -
The Impact of R10-Hydroxywarfarin on CYP2C9-Mediated S-Warfarin Metabolism
(2014-04-30)Warfarin therapy is highly effective in treating both atrial fibrillation and deep vein thrombosis. Currently, more than 20 million Americans are receiving warfarin therapy. However, increased risk of adverse events are ... -
Impact of the Vaginal Microbiome on HIV Transmission
HIV is a global epidemic affecting almost 35 million people worldwide. Each year, almost 2 million new infections occur, with over 1 million new infections in women. The majority of these new infections take place in low ... -
Impact of Warfarin Pharmacogene Variation on Drug Metabolism and Pharmacological Response in Alaska Native and American Indian Populations
The oral vitamin K antagonist warfarin (Coumadin®) is used to prevent stroke in patients with atrial fibrillation and for secondary prevention of venous thromboembolism. Despite newer treatment options such as the direct ... -
In Vitro to In Vivo Extrapolation of Transporter-Mediated Clearance of Drugs Using Quantitative Proteomics
Prediction of in vivo drug clearance (CL) is an important aspect of drug discovery and development. Our ability to predict in vivo hepatic metabolic clearance and metabolic drug-drug interactions from in vitro studies using ... -
In Vitro to In Vivo Translation of Complex Drug-Drug Interactions Involving Retinoic Acid
all-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a ligand for several nuclear receptors and acts as a critical regulator of many physiological processes. The cytochrome P450 26 (CYP26) enzymes are ... -
Influence of Perspective on Preferences for Prostate Cancer Outcomes
Background The utility value is a necessary component of the cost-utility analysis (CUA). They can be obtained from various perspectives and using different methods. The relationship between elicitation methods and ... -
Investigating the Association Between Sedative Hypnotic Prescription Exposures and Motor Vehicle Crashes
(2012-09-13)Background Motor vehicle crashes occur daily and may be fatal for the driver, passengers or bystanders. Crashes have been shown to be associated with certain medical conditions and exposure to prescription medications that ... -
Investigating the role of drug transporters in furosemide absorption, food-effect and elimination by a proteomics informed-mechanistic PBPK modeling approach
Furosemide is a widely used diuretic for treating excessive fluid accumulation caused by disease conditions like heart failure and liver cirrhosis. Furosemide exhibits variable pharmacokinetics (PK) with bioavailability ... -
Isotretinoin Administration Improves Sperm Production in Men with Infertility
University of Washington Abstract Isotretinoin Administration Improves Sperm Production in Men with Infertility John K. Amory MD, MPH Chair of the Supervisory Committee: Dr. Nina Isoherranen, Associate Professor Department ... -
Mathematical Models to Evaluate the Clinical and Economic Impact of Biomedical HIV Prevention Strategies in the United States
As the marginal clinical impact returns on innovations to treat and prevent HIV diminish, strategic investments are required for timely and efficient HIV eradication. The overall goal of this dissertation research is to ... -
Mechanistic Physiologically Based Pharmacokinetic (PBPK) Modeling of Renal and Systemic Disposition of Drugs and Metabolites
Physiologically-based pharmacokinetic (PBPK) models integrate system specific anatomy and physiology information with drug specific physicochemical and pharmacokinetic properties to predict drug disposition. Such integration ... -
Metabolic and inhibitory differences between cytochromes P450 3A4 and 3A5
(2001)Cytochrome P450 (CYP) 3A4 and 3A5 constitute the dominant drug metabolizing enzymes in the liver and small intestine, and the content and activity of these enzymes is widely variable. Accurate knowledge of in vivo CYP3A ... -
Migraine-specific health resource utilization in chronic and episodic migraine across six countries
(2012-09-13)Background: Though studies have consistently revealed variation in resource utilization between chronic and episodic migraineurs, less is known about how these differences compare across countries. This research describes ... -
Molecular and Cellular Characterization of Human Embryonic Stem Cell Derived Hepatocytes
Primary human hepatocytes are commonly used to evaluate liver drug metabolism and toxicity. Pluripotent stem cell derived hepatocytes (SCDHs) have the potential to overcome access and function-related limitations associated ... -
Molecular Mechanisms of Drug Transport at the Blood-CSF Barrier Revealed by Live Tissue Imaging and Quantitative Fluorescence Microscopy
The blood-cerebrospinal fluid barrier (BCSFB) is formed by the choroid plexus epithelial (CPE) cells, which express several polyspecific membrane transporters that contribute towards clearance of xenobiotic and endogenous ... -
Of Mice and Women: Understanding Pregnancy-Induced Changes in Glyburide PK/PD for the Improved Management of Gestational Diabetes Mellitus (GDM)
Pregnancy-induced changes in drug PK is explained by changes in physiology and expression of metabolic enzymes and transporters. We determined mRNA expression of enzymes and transporters in the maternal liver, kidney, small ...