Browsing Pharmaceutics by Title
Now showing items 72-80 of 80
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The identification and characterization of acute kidney injury (AKI) associated with systemic polymyxins in the management of severe gram-negative infections
Background The global rise in antibiotic resistance has led to an increased need for effective antimicrobial treatments. Polymyxins have re-emerged in recent years due to their strong antimicrobial activity against resistant ... -
The Polyspecific Organic Cation Transporters: Role in Cancer Drug Targeting, Xenobiotic Disposition, and Drug-drug Interactions
The polyspecific organic cation transporters (pOCTs) include the organic cation transporters (OCT1-3), the multidrug and toxin extrusion proteins (MATE1/2K) and the plasma membrane monoamine transporter (PMAT). These ... -
The Real Option Value of Life And Innovation
Background: Recent developments in healthcare value assessments have expanded the definition of value for medical technologies. The option value of a life-extending treatment is the opportunity of benefiting from future ... -
The Role of CS1 Fibronectin in HIV-1 Infection of α4β7+ T Lymphocytes
A hallmark of Human Immunodeficiency Virus type 1 (HIV-1) pathogenesis is the profound depletion of CD4+ T lymphocytes within gut-associated lymphoid tissues (GALT), and persistent immune dysfunction at mucosal sites. It ... -
The Role of Organic Cation Transporters in the Disposition, Drug-Drug Interactions, and Tissue Toxicity of Amphetamines
This dissertation research aims to elucidate the roles of organic cation transporters in the disposition, drug-drug interactions, and toxicity of methamphetamine. Work conducted in this dissertation research has elucidated ... -
The Roles of the Polyspecific Organic Cation Transporters in the Disposition of meta-Iodobenzylguanidine and Implications for Toxicities and Drug Interactions
meta-Iodobenzylguanidine (mIBG) is a radiopharmaceutical used as diagnostic agent and a targeted radiotherapy for neuroendocrine cancers. 131I-mIBG enters the cancer cells through the human norepinephrine transporter (hNET) ... -
Transporter and Metabolic-based Drug-Drug Interactions: The Blood-Brain Barrier and The Liver
(2013-04-17)The HIV Protease inhibitor (PI)-based DDIs are complex, unpredictable and often paradoxical. Investigations dedicated to evaluating PIs' potential as inducers of the CYPs and drug transporter, and PIs' as substrates of ... -
Understanding Pregnancy-induced Changes in the Disposition of Norbuprenorphine, Metformin and Glyburide in Mice and Humans for Optimizing Drug Therapy during Pregnancy
Pharmacotherapy usage during pregnancy is common and increasing. In the current clinical practice, healthcare providers are increasingly prescribing buprenorphine (BUP) for opioid addiction treatment, as well as metformin, ... -
Variations in Surgeon Treatment Preferences and The Impact on the Cost-Utility of Surgery for Soft Tissue Sarcoma
Background The primary treatment for soft tissue sarcoma (STS) is surgical excision of the tumor. There are variations in the surgical strategies used to excise the tumor. It is unknown which surgical strategy is more ...