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Browsing Pharmaceutics by Title
Now showing items 11-30 of 80
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Assessing the Impact of Health Economics and Outcomes Research Evidence on Reimbursement Decisions in the United States
Objectives: Health economics and outcomes research (HEOR) is a growing field that has gained substantial momentum in recent decades. While studies establishing a product's safety and efficacy have a well-understood role ... -
Blood safety and resource allocation: economic analyses of donated blood safety initiatives
(2003)Risk management at any cost has become the apparent policy of blood banks and regulators because of transfusion-transmitted HIV and hepatitis. However, blood bank opinion leaders suggest economic analyses of new interventions ... -
Characterization of Interindividual Variability and Differential Tissue Abundance of UGT2B17: Discovery of a Potential Biomarker and Drug Interaction Prediction
UGT2B17 is an androgen- and drug-conjugating enzyme with a remarkably high interindividual variability in its hepatic protein expression. Testosterone is one of its main endogenous substrates, and various clinical associations ... -
Characterizing bupropion metabolism, pharmacokinetics and drug-drug interaction liability
Bupropion is a norepinephrine and dopamine reuptake inhibitor that is currently indicated for use as an antidepressant (Wellbutrin), a smoking cessation aid (Zyban) and a weight loss therapy in combination with naltrexone ... -
Clinical Significance and Regulatory Framework for the Evaluation of Organic Anion Transporting Polypeptide 1B-Based Drug-Drug Interactions
This dissertation research aims to conduct a comprehensive analysis of the clinical role of organic anion transporting polypeptides (OATPs) 1B1 and 1B3 and the regulatory approach for their evaluation. The work included ... -
A Comparison, Evaluation and Accuracy Assessment of the Fluidigm (TM) Platform in Genotyping Common and Rare variants in an Alaska Native Population
(2014-04-30)<underline>A Comparison, Evaluation and Accuracy Assessment of the Fluidigm <super>(TM)</super> Platform in Genotyping Common and Rare variants in an Alaska Native Population</underline> by Joseph Yracheta Pharmacogenomics ... -
A Cost Minimization Analysis of Home versus Lab-based Diagnosis of Obstructive Sleep Apnea
(2014-04-30)Importance: Insurers have adopted new reimbursement policies for diagnosing and treating obstructive sleep apnea (OSA) using home sleep testing (HST) instead of laboratory-based strategies. Objective: We conducted an ... -
Cost-Utility Analysis of Medications for Relapsing-Remitting Multiple Sclerosis: A United States Third-Party Payer Perspective
Background: Many new disease-modifying therapies (DMTs) have recently been approved for relapsing-remitting multiple sclerosis (RRMS) in the United States. Objective: To assess the values of 10 first-line therapies for ... -
Determining the Effect of Isotretinoin on CYP2D6 and CYP3A4 Activity in Patients with Severe Acne
Cytochrome P450 2D6 (CYP2D6) and 3A4 (CYP3A4) are critical enzymes involved in the metabolism of commonly used drugs. There are high inter-individual variabilities in CYP2D6 drug-metabolizing activities, majorly caused by ... -
Development of a Cystic Fibrosis Microphysiological Model of the Kidney Proximal Tubule
Abstract: Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by a spectrum of mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), whose protein product functions as a chloride ... -
Development of a Microphysiological Model of the Kidney Proximal Tubule and Application in Predictive Toxicity Testing of Polymyxin Antibiotics
Late-stage attrition of investigational new drugs can be extremely devastating to both the drug developer as well as the patient in regard to money lost and disease left untreated, respectively. A primary reason for a ... -
Development of Long-acting Formulation of Dolutegravir Sodium for Human Immunodeficiency Virus
Human immunodeficiency virus (HIV) is an enveloped retrovirus that attacks the infected human host’s immune system by destroying CD4 lymphocytes, the cells responsible for providing protection against infections and ... -
Development of Microphysiological Models for the Assessment of Xenobiotic and Endobiotic Absorption and Disposition
Animal models and in vitro systems have long been relied upon to provide insights into the toxicology, pharmacodynamics and pharmacokinetics of investigational drug candidates before they are administered to human subjects. ... -
Discovery and Assessment of Endogenous Biomarkers of CYP2D6 Activity for Application in Clinical Studies
The activity of cytochrome P450 2D6 (CYP2D6) is highly variable due to genetic and environmental influences. Assessing CYP2D6 activity may aid in initial dosing of drugs metabolized by CYP2D6, help maximize therapeutic ... -
Drug Disposition during Pregnancy: Transport, Metabolism, and the Gut Microbiome
Medication use during pregnancy is increasingly prevalent and medically necessary to maintain maternal health. Yet, a quarter of medications used by pregnant women have unknown safety for the pregnant population. It is ... -
Dysregulation of Human Hepatic Drug Transporters by Proinflammatory Cytokines
Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced clearance of drugs eliminated primarily by cytochrome P450 enzymes (CYPs). However, the effect of ... -
The economic and clinical outcomes and policy implications of gene expression profiling in breast cancer care
(2004)In the U.S., the majority of premenopausal breast cancer patients are recommended by clinical guidelines to receive adjuvant chemotherapy to prevent disease progression and increase survival. However, low-risk patients may ... -
Elucidating Mechanisms for Drug Combination Nanoparticles to Enhance and Prolong Lymphatic Exposure: Experimental and Modeling Approaches
Human immunodeficiency virus (HIV) infection and metastatic cancers impact over 50 million people worldwide. Because HIV and metastatic cancers exploit the lymphatics to persist and spread, enhanced and prolonged lymphatic ...